{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:33:59Z","timestamp":1772138039624,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2R002514"],"award-info":[{"award-number":["OT2R002514"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01CA207160"],"award-info":[{"award-number":["1U01CA207160"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respective confirmatory pathways of drug action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>COVID-KOP is freely accessible at https:\/\/covidkop.renci.org\/. For code and instructions for the original ROBOKOP, see: https:\/\/github.com\/NCATS-Gamma\/robokop.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa718","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T10:45:44Z","timestamp":1605005144000},"page":"586-587","source":"Crossref","is-referenced-by-count":14,"title":["COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-9872","authenticated-orcid":false,"given":"Daniel","family":"Korn","sequence":"first","affiliation":[{"name":"Department of Computer Science, University of North Carolina at Chapel Hill , USA"}]},{"given":"Tesia","family":"Bobrowski","sequence":"additional","affiliation":[{"name":"Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , USA"}]},{"given":"Michael","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of North Carolina at Chapel Hill , USA"}]},{"given":"Yaphet","family":"Kebede","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7568, USA"}]},{"given":"Patrick","family":"Wang","sequence":"additional","affiliation":[{"name":"CoVar Applied Technologies , Durham, NC 27701, USA"}]},{"given":"Phillips","family":"Owen","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7568, USA"}]},{"given":"Gaurav","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7568, USA"}]},{"given":"Eugene","family":"Muratov","sequence":"additional","affiliation":[{"name":"Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , USA"}]},{"given":"Rada","family":"Chirkova","sequence":"additional","affiliation":[{"name":"Department of Computer Science, North Carolina State University , Raleigh, NC 27606-5550, USA"}]},{"given":"Chris","family":"Bizon","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7568, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-8896","authenticated-orcid":false,"given":"Alexander","family":"Tropsha","sequence":"additional","affiliation":[{"name":"Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , USA"}]}],"member":"286","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"2023051706080038600_btaa718-B1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. 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