{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:12:17Z","timestamp":1774386737315,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish National Bioinformatics Institute","award":["PT17\/0009\/0011 \u2013 ISCIII-SGEFI\/ERDF"],"award-info":[{"award-number":["PT17\/0009\/0011 \u2013 ISCIII-SGEFI\/ERDF"]}]},{"name":"RETOS","award":["RTI2018-097596-B-I00"],"award-info":[{"award-number":["RTI2018-097596-B-I00"]}]},{"DOI":"10.13039\/100016778","name":"Paradifference Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016778","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Severo Ochoa FPI"},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["PEJD-2019-PRE\/BMD-15732"],"award-info":[{"award-number":["PEJD-2019-PRE\/BMD-15732"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"C. de Educaci\u00f3n, Universidades e Formaci\u00f3n Profesional","award":["ED431C2018\/55-GRC"],"award-info":[{"award-number":["ED431C2018\/55-GRC"]}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PI-0173-2017"],"award-info":[{"award-number":["PI-0173-2017"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and \u223c2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug\u2013signature association scores, FDRs and downloadable plots and results tables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availabilityand implementation<\/jats:title>\n                    <jats:p>http:\/\/www.dreimt.org.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa727","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T15:06:42Z","timestamp":1597590402000},"page":"578-579","source":"Crossref","is-referenced-by-count":16,"title":["DREIMT: a drug repositioning database and prioritization tool for immunomodulation"],"prefix":"10.1093","volume":"37","author":[{"given":"Kevin","family":"Troul\u00e9","sequence":"first","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre (CNIO) , Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"SING Research Group, Biomedical Research Centre (CINBIO), E-36310, Vigo, Spain"},{"name":"ESEI - Escuela Superior de Ingenier\u00eda Inform\u00e1tica, Department of Computer Science, Universidad de Vigo, E-32004, Ourense, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre (CNIO) , Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Reboiro-Jato","sequence":"additional","affiliation":[{"name":"SING Research Group, Biomedical Research Centre (CINBIO), E-36310, Vigo, Spain"},{"name":"ESEI - Escuela Superior de Ingenier\u00eda Inform\u00e1tica, Department of Computer Science, Universidad de Vigo, E-32004, Ourense, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Carretero-Puche","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre (CNIO) , Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Martorell-Marug\u00e1n","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, GENYO, Centre for Genomics and Oncological Research, Pfizer\/University of Granada\/Andalusian Regional Government , PTS Granada, E-18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Mart\u00edn-Serrano","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre (CNIO) , Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Carmona-S\u00e1ez","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, GENYO, Centre for Genomics and Oncological Research, Pfizer\/University of Granada\/Andalusian Regional Government , PTS Granada, E-18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Glez-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"SING Research Group, Biomedical Research Centre (CINBIO), E-36310, Vigo, Spain"},{"name":"ESEI - Escuela Superior de Ingenier\u00eda Inform\u00e1tica, Department of Computer Science, Universidad de Vigo, E-32004, Ourense, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-769X","authenticated-orcid":false,"given":"F\u00e1tima","family":"Al-Shahrour","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre (CNIO) , Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"G\u00f3mez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre (CNIO) , Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"2023051706074000600_btaa727-B1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev-chembioeng-080615-034446","article-title":"Nanoparticle-based modulation of the immune system","volume":"7","author":"Fang","year":"2016","journal-title":"Annu. 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