{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:00Z","timestamp":1772138040615,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research And Innovation Programme","award":["851018"],"award-info":[{"award-number":["851018"]}]},{"name":"Adams Fellowships Program"},{"DOI":"10.13039\/501100003973","name":"Israel Academy of Sciences and Humanities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Recent years have seen a growing number and an expanding scope of studies using synthetic oligo libraries for a range of applications in synthetic biology. As experiments are growing by numbers and complexity, analysis tools can facilitate quality control and support better assessment and inference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We present a novel analysis tool, called SOLQC, which enables fast and comprehensive analysis of synthetic oligo libraries, based on NGS analysis performed by the user. SOLQC provides statistical information such as the distribution of variant representation, different error rates and their dependence on sequence or library properties. SOLQC produces graphical reports from the analysis, in a flexible format. We demonstrate SOLQC by analyzing literature libraries. We also discuss the potential benefits and relevance of the different components of the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>SOLQC is a free software for non-commercial use, available at https:\/\/app.gitbook.com\/@yoav-orlev\/s\/solqc\/. For commercial use please contact the authors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa740","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T07:45:25Z","timestamp":1597823125000},"page":"720-722","source":"Crossref","is-referenced-by-count":30,"title":["SOLQC: Synthetic Oligo Library Quality Control tool"],"prefix":"10.1093","volume":"37","author":[{"given":"Omer","family":"Sabary","sequence":"first","affiliation":[{"name":"The Henry and Marilyn Taub Faculty of Computer Science , Technion, Haifa, 3200003, Israel"}]},{"given":"Yoav","family":"Orlev","sequence":"additional","affiliation":[{"name":"School of Computer Science, Herzliya Interdisciplinary Center , Herzliya 4610101, Israel"}]},{"given":"Roy","family":"Shafir","sequence":"additional","affiliation":[{"name":"The Henry and Marilyn Taub Faculty of Computer Science , Technion, Haifa, 3200003, Israel"},{"name":"School of Computer Science, Herzliya Interdisciplinary Center , Herzliya 4610101, Israel"}]},{"given":"Leon","family":"Anavy","sequence":"additional","affiliation":[{"name":"The Henry and Marilyn Taub Faculty of Computer Science , Technion, Haifa, 3200003, Israel"}]},{"given":"Eitan","family":"Yaakobi","sequence":"additional","affiliation":[{"name":"The Henry and Marilyn Taub Faculty of Computer Science , Technion, Haifa, 3200003, Israel"}]},{"given":"Zohar","family":"Yakhini","sequence":"additional","affiliation":[{"name":"The Henry and Marilyn Taub Faculty of Computer Science , Technion, Haifa, 3200003, Israel"},{"name":"School of Computer Science, Herzliya Interdisciplinary Center , Herzliya 4610101, Israel"}]}],"member":"286","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"2023051704110305300_btaa740-B1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41587-019-0240-x","article-title":"Data storage in DNA with fewer synthesis cycles using composite DNA letters","volume":"37","author":"Anavy","year":"2019","journal-title":"Nat. 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