{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:06:38Z","timestamp":1762376798316,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2627-E-002-001-","109-2320-B-002-040-","109-2926-I-002-506-"],"award-info":[{"award-number":["108-2627-E-002-001-","109-2320-B-002-040-","109-2926-I-002-506-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Taiwan University, Taiwan","award":["NTU-CC-109L892703"],"award-info":[{"award-number":["NTU-CC-109L892703"]}]},{"DOI":"10.13039\/100009210","name":"Taiwan Food and Drug Administration","doi-asserted-by":"publisher","award":["109-FDA-D-114-000611"],"award-info":[{"award-number":["109-FDA-D-114-000611"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Drug discovery targeting G protein-coupled receptors (GPCRs), the largest known class of therapeutic targets, is challenging. To facilitate the rapid discovery and development of GPCR drugs, we built a system, PanGPCR, to predict multiple potential GPCR targets and their expression locations in the tissues, side effects and possible repurposing of GPCR drugs. With PanGPCR, the compound of interest is docked to a library of 36 experimentally determined crystal structures comprising of 46 docking sites for human GPCRs, and a ranked list is generated from the docking studies to assess all GPCRs and their binding affinities. Users can determine a given compound\u2019s GPCR targets and its repurposing potential accordingly. Moreover, potential side effects collected from the SIDER (Side-Effect Resource) database and mapped to 45 tissues and organs are provided by linking predicted off-targets and their expressed sequence tag profiles. With PanGPCR, multiple targets, repurposing potential and side effects can be determined by simply uploading a small ligand.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>PanGPCR is freely accessible at https:\/\/gpcrpanel.cmdm.tw\/index.html.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa766","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T19:14:41Z","timestamp":1598642081000},"page":"1184-1186","source":"Crossref","is-referenced-by-count":4,"title":["PanGPCR: predictions for multiple targets, repurposing and side effects"],"prefix":"10.1093","volume":"37","author":[{"given":"Lu-Chi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yang","family":"Ho","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Han","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University , Taipei 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Tsung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Genome and Systems Biology Degree Program, National Taiwan University , Taipei, 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8461-6181","authenticated-orcid":false,"given":"Yufeng J","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei 106, Taiwan"},{"name":"Genome and Systems Biology Degree Program, National Taiwan University , Taipei, 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"2023051612055728500_btaa766-B1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.acvd.2013.02.003","article-title":"Drug-induced valvular heart disease: an update","volume":"106","author":"Andrejak","year":"2013","journal-title":"Arch. 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