{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:57:17Z","timestamp":1773115037157,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["389522"],"award-info":[{"award-number":["389522"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2014-04514"],"award-info":[{"award-number":["RGPIN-2014-04514"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["P41GM103399"],"award-info":[{"award-number":["P41GM103399"]}]},{"name":"National Institute of Health","award":["GM100310"],"award-info":[{"award-number":["GM100310"]}]},{"name":"National Institute of Health","award":["HL144130"],"award-info":[{"award-number":["HL144130"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DBI-1902076"],"award-info":[{"award-number":["DBI-1902076"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010346","name":"University of Colorado Denver","doi-asserted-by":"publisher","award":["STYPE 61193205"],"award-info":[{"award-number":["STYPE 61193205"]}],"id":[{"id":"10.13039\/100010346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Correlated Nuclear Magnetic Resonance (NMR) chemical shift changes identified through the CHEmical Shift Projection Analysis (CHESPA) and CHEmical Shift Covariance Analysis (CHESCA) reveal pathways of allosteric transitions in biological macromolecules. To address the need for an automated platform that implements CHESPA and CHESCA and integrates them with other NMR analysis software packages, we introduce here integrated plugins for NMRFAM-SPARKY that implement the seamless detection and visualization of allosteric networks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>CHESCA-SPARKY and CHESPA-SPARKY are available in the latest version of NMRFAM-SPARKY from the National Magnetic Resonance Facility at Madison (http:\/\/pine.nmrfam.wisc.edu\/download_packages.html), the NMRbox Project (https:\/\/nmrbox.org) and to subscribers to the SBGrid (https:\/\/sbgrid.org). The assigned spectra involved in this study and tutorial videos using this dataset are available at https:\/\/sites.google.com\/view\/chescachespa-sparky.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics Online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa781","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:15:38Z","timestamp":1599074138000},"page":"1176-1177","source":"Crossref","is-referenced-by-count":13,"title":["CHESPA\/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery"],"prefix":"10.1093","volume":"37","author":[{"given":"Hongzhao","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology , Hamilton, ON L8S 4L8, Canada"}]},{"given":"Stephen","family":"Boulton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, ON L8S 4L8, Canada"}]},{"given":"Cristina","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics , Minneapolis, MN 55455, USA"}]},{"given":"Hebatallah","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology , Hamilton, ON L8S 4L8, Canada"}]},{"given":"Madoka","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology , Hamilton, ON L8S 4L8, Canada"}]},{"given":"Manu Veliparambil","family":"Subrahmanian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics , Minneapolis, MN 55455, USA"}]},{"given":"Gianluigi","family":"Veglia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics , Minneapolis, MN 55455, USA"},{"name":"Department of Chemistry, University of Minnesota , Minneapolis, MN 55455, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-6134","authenticated-orcid":false,"given":"John L","family":"Markley","sequence":"additional","affiliation":[{"name":"Biochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison , Madison, WI 53717, USA"}]},{"given":"Giuseppe","family":"Melacini","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology , Hamilton, ON L8S 4L8, Canada"},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, ON L8S 4L8, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-203X","authenticated-orcid":false,"given":"Woonghee","family":"Lee","sequence":"additional","affiliation":[{"name":"Biochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison , Madison, WI 53717, USA"},{"name":"Department of Chemistry, University of Colorado Denver , Denver, CO 80217, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"2023051701214383500_btaa781-B1","doi-asserted-by":"crossref","first-page":"14231","DOI":"10.1073\/pnas.1312644110","article-title":"Signaling through dynamic linkers as revealed by PKA","volume":"110","author":"Akimoto","year":"2013","journal-title":"Proc. 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