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Strong evidences have implicated the high dependence of CDR on tumor genomic and transcriptomic profiles of individual patients. Precise identification of CDR is crucial in both guiding anti-cancer drug design and understanding cancer biology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this study, we present DeepCDR which integrates multi-omics profiles of cancer cells and explores intrinsic chemical structures of drugs for predicting CDR. Specifically, DeepCDR is a hybrid graph convolutional network consisting of a uniform graph convolutional network and multiple subnetworks. Unlike prior studies modeling hand-crafted features of drugs, DeepCDR automatically learns the latent representation of topological structures among atoms and bonds of drugs. Extensive experiments showed that DeepCDR outperformed state-of-the-art methods in both classification and regression settings under various data settings. We also evaluated the contribution of different types of omics profiles for assessing drug response. Furthermore, we provided an exploratory strategy for identifying potential cancer-associated genes concerning specific cancer types. Our results highlighted the predictive power of DeepCDR and its potential translational value in guiding disease-specific drug design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>DeepCDR is freely available at https:\/\/github.com\/kimmo1019\/DeepCDR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa822","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T07:13:34Z","timestamp":1602486814000},"page":"i911-i918","source":"Crossref","is-referenced-by-count":228,"title":["DeepCDR: a hybrid graph convolutional network for predicting cancer drug response"],"prefix":"10.1093","volume":"36","author":[{"given":"Qiao","family":"Liu","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Bioinformatics, Research Department of Bioinformatics, Beijing National Research Center, Information Science and Technology, Center for Synthetic and Systems Biology"},{"name":"Department of Automation, Tsinghua University , Beijing 100084, China"}]},{"given":"Zhiqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Automation, Tsinghua University , Beijing 100084, China"},{"name":"SenseTime Research , Shanghai 200233, China"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Bioinformatics, Research Department of Bioinformatics, Beijing National Research Center, Information Science and Technology, Center for Synthetic and Systems Biology"},{"name":"Department of Automation, Tsinghua University , Beijing 100084, China"}]},{"given":"Mu","family":"Zhou","sequence":"additional","affiliation":[{"name":"SenseBrain Research , San Jose, CA 95131, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"2023062409322468700_btaa822-B1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"2023062409322468700_btaa822-B2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ymeth.2014.08.005","article-title":"Molecular fingerprint similarity search in virtual screening","volume":"71","author":"Cereto-Massagu\u00e9","year":"2015","journal-title":"Methods"},{"key":"2023062409322468700_btaa822-B3","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1038\/s41598-018-27214-6","article-title":"Cancer drug response profile scan (CDRscan): a deep learning model that predicts drug effectiveness from cancer genomic signature","volume":"8","author":"Chang","year":"2018","journal-title":"Sci. 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