{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T03:39:33Z","timestamp":1775878773274,"version":"3.50.1"},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministerio de Ciencia; Innovaci\u00f3n y Universidades","award":["RTI2018-100789-B-I00"],"award-info":[{"award-number":["RTI2018-100789-B-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,19]]},"abstract":"Abstract<\/jats:title>\n \n Motivation<\/jats:title>\n Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We developed a Bioconductor package that allows computation of several existing DNAm adult\/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types\u2019 estimates, that are required for DNAm age clocks.<\/jats:p>\n <\/jats:sec>\n \n Availability and implementation<\/jats:title>\n https:\/\/github.com\/isglobal-brge\/methylclock.<\/jats:p>\n <\/jats:sec>\n \n Supplementary information<\/jats:title>\n Supplementary data are available at Bioinformatics online.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa825","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T11:11:23Z","timestamp":1599563483000},"page":"1759-1760","source":"Crossref","is-referenced-by-count":196,"title":["methylclock<\/i>: a Bioconductor package to estimate DNA methylation age"],"prefix":"10.1093","volume":"37","author":[{"given":"Dolors","family":"Peleg\u00ed-Sis\u00f3","sequence":"first","affiliation":[{"name":"Barcelona Research Institute for Global Health (ISGlobal) , Barcelona, Spain"}]},{"given":"Paula","family":"de Prado","sequence":"additional","affiliation":[{"name":"Barcelona Research Institute for Global Health (ISGlobal) , Barcelona, Spain"}]},{"given":"Justiina","family":"Ronkainen","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research, University of Oulu , Oulu, Finland"}]},{"given":"Mariona","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Barcelona Research Institute for Global Health (ISGlobal) , Barcelona, Spain"},{"name":"CIBER in Epidemiology (CIBERESP) , Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-2146","authenticated-orcid":false,"given":"Juan R","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Barcelona Research Institute for Global Health (ISGlobal) , Barcelona, Spain"},{"name":"CIBER in Epidemiology (CIBERESP) , Madrid, Spain"}]}],"member":"286","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"2023051709460798100_btaa825-B1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol. Cell"},{"key":"2023051709460798100_btaa825-B2","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"key":"2023051709460798100_btaa825-B3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1080\/15592294.2015.1057384","article-title":"A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data","volume":"10","author":"Wang","year":"2015","journal-title":"Epigenetics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btaa825\/38499543\/btaa825.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/37\/12\/1759\/50361297\/btaa825.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/37\/12\/1759\/50361297\/btaa825.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T10:31:48Z","timestamp":1684319508000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/37\/12\/1759\/5909987"}},"subtitle":[],"editor":[{"given":"Peter","family":"Robinson","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":3,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,7,19]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btaa825","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6,15]]},"published":{"date-parts":[[2020,9,22]]}}}