{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:51:09Z","timestamp":1759693869050,"version":"3.37.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801061","81803651"],"award-info":[{"award-number":["31801061","81803651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2017LB018"],"award-info":[{"award-number":["ZR2017LB018"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Exposure of mouse embryos to atrazine decreased histone tri-methylation at lysine 4 (H3K4me3) and increased expression of alternatively spliced RNA in the third generation. Specificity protein (SP) family motifs were enriched in the promoters of genes encoding differentially expressed alternative transcripts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>H3K4me3 chromatin immunoprecipitation sequencing (ChIP-seq) of mouse sperm, preimplantation embryo development and male gonad primordial germ cells (PGCs) were analysed to identify the paternal reprogramming-escape H3K4me3 regions (RERs). In total, 251 RERs selected harbour H3K4me3 marks in sperm, with signals occurring in the paternal genome during early development and in male gonad PGCs, and 179 genes had RERs within 1\u2009kb of transcription start sites (TSSs). These genes were significantly enriched in the gene ontology term \u2018RNA splicing\u2019, and SP1\/SP2\/SP3 motifs were enriched in RER-associated H3K4me3 peaks. Overall, the H3K4me3 marks within TSSs of RNA splicing genes survived two rounds of the epigenetic reprogramming process.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa920","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T11:43:08Z","timestamp":1602762188000},"page":"1039-1044","source":"Crossref","is-referenced-by-count":8,"title":["Paternal reprogramming-escape histone H3K4me3 marks located within promoters of RNA splicing genes"],"prefix":"10.1093","volume":"37","author":[{"given":"Nan","family":"Hao","sequence":"first","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"},{"name":"School of Mathematics and Statistics, Wuhan University ,\u00a0Wuhan 430072, China"}]},{"given":"Huawei","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]},{"given":"Xiaowei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]},{"given":"Jie","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]},{"given":"Haijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]},{"given":"Shaofen","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-3816","authenticated-orcid":false,"given":"Chunxiang","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Linyi University ,\u00a0Linyi 276000, China"}]}],"member":"286","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"2023051612065081400_btaa920-B1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","author":"Anway","year":"2005","journal-title":"Science"},{"key":"2023051612065081400_btaa920-B2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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