{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:02:36Z","timestamp":1774119756752,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U24CA210978"],"award-info":[{"award-number":["U24CA210978"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gray Matters Brain Cancer Foundation"},{"DOI":"10.13039\/100001794","name":"Pediatric Brain Tumor Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alison Poorvu Jaffe"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The expansion of targeted panel sequencing efforts has created opportunities for large-scale genomic analysis, but tools for copy-number quantification on panel data are lacking. We introduce ASCETS, a method for the efficient quantitation of arm and chromosome-level copy-number changes from targeted sequencing data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>ASCETS is implemented in R and is freely available to non-commercial users on GitHub: https:\/\/github.com\/beroukhim-lab\/ascets, along with detailed documentation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa980","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:11:49Z","timestamp":1605096709000},"page":"2461-2463","source":"Crossref","is-referenced-by-count":51,"title":["Quantification of aneuploidy in targeted sequencing data using ASCETS"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-7739","authenticated-orcid":false,"given":"Liam F","family":"Spurr","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"},{"name":"Cancer Program, Broad Institute of MIT and Harvard , Cambridge, 02142 MA, USA"}]},{"given":"Mehdi","family":"Touat","sequence":"additional","affiliation":[{"name":"Cancer Program, Broad Institute of MIT and Harvard , Cambridge, 02142 MA, USA"},{"name":"Department of Oncologic Pathology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"},{"name":"Sorbonne Universit\u00e9, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM, AP-HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2014Charles Foix, Service de Neurologie , Paris, France"}]},{"given":"Alison M","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"},{"name":"Cancer Program, Broad Institute of MIT and Harvard , Cambridge, 02142 MA, USA"},{"name":"Department of Pathology and Cell Biology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center , New York, 10032 NY, USA"}]},{"given":"Adrian M","family":"Dubuc","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital , Boston, 02215 MA, USA"}]},{"given":"Juliann","family":"Shih","sequence":"additional","affiliation":[{"name":"Cancer Program, Broad Institute of MIT and Harvard , Cambridge, 02142 MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-8624","authenticated-orcid":false,"given":"David M","family":"Meredith","sequence":"additional","affiliation":[{"name":"Department of Oncologic Pathology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"},{"name":"Department of Pathology, Brigham and Women\u2019s Hospital , Boston, 02215 MA, USA"}]},{"given":"William V","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Oncologic Pathology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"}]},{"given":"Matthew L","family":"Meyerson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"},{"name":"Cancer Program, Broad Institute of MIT and Harvard , Cambridge, 02142 MA, USA"}]},{"given":"Keith L","family":"Ligon","sequence":"additional","affiliation":[{"name":"Cancer Program, Broad Institute of MIT and Harvard , Cambridge, 02142 MA, USA"},{"name":"Department of Oncologic Pathology, Dana-Farber Cancer Institute , Boston, 02215 MA, USA"},{"name":"Department of Pathology, Brigham and Women\u2019s Hospital , Boston, 02215 MA, USA"},{"name":"Center for Patient Derived Models, Dana-Farber Cancer Institute , Boston, 02215 MA, 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