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With the rapid development of single-cell RNA sequencing (scRNA-seq) technologies, systematically decoding the intercellular communication network involving L\u2013R interactions has become a focus of research. Therefore, construction of a comprehensive, high-confidence and well-organized resource to retrieve L\u2013R interactions in order to study the functional effects of cell\u2013cell communications would be of great value.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this study, we developed Cellinker, a platform of literature-supported L\u2013R interactions that play roles in cell\u2013cell communication. We aimed to provide a useful platform for studies on cell\u2013cell communication mediated by L\u2013R interactions. The current version of Cellinker documents over 3700 human and 3200 mouse L\u2013R protein\u2013protein interactions (PPIs) and embeds a practical and convenient webserver with which researchers can decode intercellular communications based on scRNA-seq data. And over 400 endogenous small molecule (sMOL) related L\u2013R interactions were collected as well. Moreover, to help with research on coronavirus (CoV) infection, Cellinker collects information on 16L\u2013R PPIs involved in CoV\u2013human interactions (including 12L\u2013R PPIs involved in SARS-CoV-2 infection). In summary, Cellinker provides a user-friendly interface for querying, browsing and visualizing L\u2013R interactions as well as a practical and convenient web tool for inferring intercellular communications based on scRNA-seq data. We believe this platform could promote intercellular communication research and accelerate the development of related algorithms for scRNA-seq studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Cellinker is available at http:\/\/www.rna-society.org\/cellinker\/<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab036","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:20:26Z","timestamp":1610713226000},"page":"2025-2032","source":"Crossref","is-referenced-by-count":86,"title":["Cellinker: a platform of ligand\u2013receptor interactions for intercellular communication analysis"],"prefix":"10.1093","volume":"37","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan) , Foshan 528308, China"}]},{"given":"Tianyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University , Guangzhou 510515, China"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University , Guangzhou 510515, China"}]},{"given":"Bohao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of California Davis , Davis, CA 95616, USA"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harbin Medical University , Harbin 150081, China"}]},{"given":"Linhui","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University , Guangzhou 510515, China"}]},{"given":"Kechen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University , Guangzhou 510515, China"}]},{"given":"Lin","family":"Ning","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University , Guangzhou 510091, China"}]},{"given":"Bingyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan) , Foshan 528308, China"}]},{"given":"Xiaoyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan) , Foshan 528308, China"},{"name":"State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University , Guangzhou 510515, China"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan) , Foshan 528308, China"},{"name":"Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University , Guangzhou 510515, China"},{"name":"Dermatology Hospital, Southern Medical University , Guangzhou 510091, China"}]}],"member":"286","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"2023061310295359400_btab036-B1","first-page":"D1006","article-title":"The IUPHAR\/BPS guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR\/MMV guide to MALARIA PHARMACOLOGY","volume":"48","author":"Armstrong","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2023061310295359400_btab036-B2","doi-asserted-by":"crossref","first-page":"Re9","DOI":"10.1126\/stke.2003.187.re9","article-title":"Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction","volume":"2003","author":"Ben-Shlomo","year":"2003","journal-title":"Science's STKE"},{"key":"2023061310295359400_btab036-B3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41592-018-0009-z","article-title":"Mapping the physical network of cellular interactions","volume":"15","author":"Boisset","year":"2018","journal-title":"Nat. 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