{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:59:43Z","timestamp":1772344783455,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Science Center","award":["2019\/33\/B\/ST6\/00875"],"award-info":[{"award-number":["2019\/33\/B\/ST6\/00875"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>Queueing theory can be effective in simulating biochemical reactions taking place in living cells, and the article paves a step toward development of a comprehensive model of cell metabolism. Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals needed to evaluate drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The article presents a Krebs cycle model based on queueing theory. The model allows for tracking of metabolites concentration changes in real time. To validate the model, a drug-induced inhibition affecting activity of enzymes involved in Krebs cycle was simulated and compared with available experimental data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availabilityand implementation<\/jats:title><jats:p>The source code is freely available for download at https:\/\/github.com\/UTP-WTIiE\/KrebsCycleUsingQueueingTheory, implemented in C# supported in Linux or MS Windows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab177","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T04:12:41Z","timestamp":1615522361000},"page":"2912-2919","source":"Crossref","is-referenced-by-count":14,"title":["Queueing theory model of Krebs cycle"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-9302","authenticated-orcid":false,"given":"Sylwester","family":"Kloska","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum , 85-067 Bydgoszcz, Poland"}]},{"given":"Krzysztof","family":"Pa\u0142czy\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Telecommunications, Computer Science and Electrical Engineering, UTP University of Science and Technology , 85-796 Bydgoszcz, Poland"}]},{"given":"Tomasz","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Faculty of Telecommunications, Computer Science and Electrical Engineering, UTP University of Science and Technology , 85-796 Bydgoszcz, Poland"}]},{"given":"Tomasz","family":"Tala\u015bka","sequence":"additional","affiliation":[{"name":"Faculty of Telecommunications, Computer Science and Electrical Engineering, UTP University of Science and Technology , 85-796 Bydgoszcz, Poland"}]},{"given":"Marissa","family":"Nitz","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Nebraska-Lincoln , Omaha, NE 68182, USA"}]},{"given":"Beata J","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Nebraska at Omaha , Omaha, NE 68182, USA"}]},{"given":"Paul","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Nebraska at Omaha , Omaha, NE 68182, USA"}]},{"given":"Tadeusz A","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Faculty of Telecommunications, Computer Science and Electrical Engineering, UTP University of Science and Technology , 85-796 Bydgoszcz, Poland"},{"name":"Department of Electrical and Computer Engineering, University of Nebraska-Lincoln , Omaha, NE 68182, USA"}]}],"member":"286","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"2023061310574367400_btab177-B1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.15252\/msb.20177763","article-title":"Temporal fluxomics reveals oscillations in TCA cycle flux throughout the mammalian cell cycle","volume":"13","author":"Ahn","year":"2017","journal-title":"Mol. 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