{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:14:37Z","timestamp":1774559677083,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health Center of Excellence in Genomic Science","award":["HG004233"],"award-info":[{"award-number":["HG004233"]}]},{"name":"National Institutes of Health Center of Excellence in Genomic Science","award":["HG010461"],"award-info":[{"award-number":["HG010461"]}]},{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Institutes of Health Foundation"},{"name":"One Brave Idea Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Multiplexed assays of variant effect (MAVEs) are capable of experimentally testing all possible single nucleotide or amino acid variants in selected genomic regions, generating \u2018variant effect maps\u2019, which provide biochemical insight and functional evidence to enable more rapid and accurate clinical interpretation of human variation. Because the international community applying MAVE approaches is growing rapidly, we developed the online MaveRegistry platform to catalyze collaboration, reduce redundant efforts, allow stakeholders to nominate targets and enable tracking and sharing of progress on ongoing MAVE projects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>MaveRegistry service: https:\/\/registry.varianteffect.org. MaveRegistry source code: https:\/\/github.com\/kvnkuang\/maveregistry-front-end.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab215","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T16:11:07Z","timestamp":1616775067000},"page":"3382-3383","source":"Crossref","is-referenced-by-count":21,"title":["MaveRegistry: a collaboration platform for multiplexed assays of variant effect"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-0464","authenticated-orcid":false,"given":"Da","family":"Kuang","sequence":"first","affiliation":[{"name":"Donnelly Centre, University of Toronto , Toronto, ON M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, ON M5S 1A8, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON M5G 1X5, Canada"},{"name":"Department of Computer Science, University of Toronto , Toronto, ON M5T 3A1, Canada"}]},{"given":"Jochen","family":"Weile","sequence":"additional","affiliation":[{"name":"Donnelly Centre, University of Toronto , Toronto, ON M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, ON M5S 1A8, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON M5G 1X5, Canada"},{"name":"Department of Computer Science, University of Toronto , Toronto, ON M5T 3A1, Canada"}]},{"given":"Nishka","family":"Kishore","sequence":"additional","affiliation":[{"name":"Donnelly Centre, University of Toronto , Toronto, ON M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, ON M5S 1A8, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON M5G 1X5, Canada"},{"name":"Department of Computer Science, University of Toronto , Toronto, ON M5T 3A1, Canada"}]},{"given":"Maria","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Donnelly Centre, University of Toronto , Toronto, ON M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, ON M5S 1A8, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON M5G 1X5, Canada"},{"name":"Department of Computer Science, University of Toronto , Toronto, ON M5T 3A1, Canada"}]},{"given":"Alan F","family":"Rubin","sequence":"additional","affiliation":[{"name":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, VIC 3052, Australia"},{"name":"Department of Medical Biology, University of Melbourne , Melbourne, VIC 3010, Australia"}]},{"given":"Stanley","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington , Seattle, WA 98195, USA"},{"name":"Department of Medicine, University of Washington , Seattle, WA 98195, USA"}]},{"given":"Douglas M","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington , Seattle, WA 98195, USA"},{"name":"Department of Bioengineering, University of Washington , Seattle, WA 98105, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-649X","authenticated-orcid":false,"given":"Frederick P","family":"Roth","sequence":"additional","affiliation":[{"name":"Donnelly Centre, University of Toronto , Toronto, ON M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, ON M5S 1A8, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON M5G 1X5, Canada"},{"name":"Department of Computer Science, University of Toronto , Toronto, ON M5T 3A1, Canada"}]}],"member":"286","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"2023051608272577900_btab215-B1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/ng0904-921","article-title":"The Knockout Mouse Project","volume":"36","author":"Austin","year":"2004","journal-title":"Nat. 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