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Ensemble fusion calling techniques appear promising; however, current options have limited accessibility and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MetaFusion is a flexible metacalling tool that amalgamates outputs from any number of fusion callers. Individual caller results are standardized by conversion into the new file type Common Fusion Format. Calls are annotated, merged using graph clustering, filtered and ranked to provide a final output of high-confidence candidates. MetaFusion consistently achieves higher precision and recall than individual callers on real and simulated datasets, and reaches up to 100% precision, indicating that ensemble calling is imperative for high-confidence results. MetaFusion uses FusionAnnotator to annotate calls with information from cancer fusion databases and is provided with a Benchmarking Toolkit to calibrate new callers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>MetaFusion is freely available at https:\/\/github.com\/ccmbioinfo\/MetaFusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab249","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T19:07:55Z","timestamp":1618859275000},"page":"3144-3151","source":"Crossref","is-referenced-by-count":15,"title":["MetaFusion: a high-confidence metacaller for filtering and prioritizing RNA-seq gene fusion candidates"],"prefix":"10.1093","volume":"37","author":[{"given":"Michael","family":"Apostolides","sequence":"first","affiliation":[{"name":"Centre for Computational Medicine, The Hospital For Sick Children , Toronto, ON, Canada"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Centre for Computational Medicine, The Hospital For Sick Children , Toronto, ON, Canada"}]},{"given":"Mia","family":"Husi\u0107","sequence":"additional","affiliation":[{"name":"Centre for Computational Medicine, The Hospital For Sick Children , Toronto, ON, Canada"}]},{"given":"Robert","family":"Siddaway","sequence":"additional","affiliation":[{"name":"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children , Toronto, ON, Canada"}]},{"given":"Cynthia","family":"Hawkins","sequence":"additional","affiliation":[{"name":"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children , Toronto, ON, Canada"},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, ON, Canada"},{"name":"Division of Pathology, The Hospital for Sick Children , Toronto, ON, Canada"}]},{"given":"Andrei L","family":"Turinsky","sequence":"additional","affiliation":[{"name":"Centre for Computational Medicine, The Hospital For Sick Children , Toronto, ON, Canada"}]},{"given":"Michael","family":"Brudno","sequence":"additional","affiliation":[{"name":"Centre for Computational Medicine, The Hospital For Sick Children , Toronto, ON, Canada"},{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children , Toronto, ON, Canada"},{"name":"Department of Computer Science, University of Toronto , Toronto, ON, Canada"},{"name":"University Health Network , Toronto, ON, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-8523","authenticated-orcid":false,"given":"Arun K","family":"Ramani","sequence":"additional","affiliation":[{"name":"Centre for Computational Medicine, The Hospital For Sick Children , Toronto, ON, Canada"}]}],"member":"286","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"2023051608283594200_btab249-B1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12918-014-0097-z","article-title":"Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer","volume":"8","author":"Abate","year":"2014","journal-title":"BMC Syst. 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