{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:31:45Z","timestamp":1768285905806,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EMBL core funding","award":["OTAR-044"],"award-info":[{"award-number":["OTAR-044"]}]},{"name":"EMBL core funding","award":["OTAR02-048"],"award-info":[{"award-number":["OTAR02-048"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["#3367"],"award-info":[{"award-number":["#3367"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["P41 GM103504"],"award-info":[{"award-number":["P41 GM103504"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Summary<\/jats:title><jats:p>IntAct App is a Cytoscape 3 application that grants in-depth access to IntAct\u2019s molecular interaction data. It build networks where nodes are interacting molecules (mainly proteins, but also genes, RNA, chemicals\u2026) and edges represent evidence of interaction. Users can query a network by providing its molecules, identified by different fields and optionally include all their interacting partners in the resulting network. The app offers three visualizations: one only displaying interactions, another representing every evidence and the last one emphasizing evidence where mutated versions of proteins were used. Users can also filter networks and click on nodes and edges to access all their related details. Finally, the application supports automation of its main features via Cytoscape commands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>Implementation available at https:\/\/apps.cytoscape.org\/apps\/intactapp, while the source code is available at https:\/\/github.com\/EBI-IntAct\/IntactApp.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab319","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T20:31:57Z","timestamp":1619555517000},"page":"3684-3685","source":"Crossref","is-referenced-by-count":33,"title":["IntAct App: a Cytoscape application for molecular interaction network visualization and analysis"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7876-6503","authenticated-orcid":false,"given":"Eliot","family":"Ragueneau","sequence":"first","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, \u00a0Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Anjali","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, \u00a0Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"John H","family":"Morris","sequence":"additional","affiliation":[{"name":"Resource for Biocomputing, Visualization, and Informatics, Department of Pharmaceutical Chemistry, University of California , San Francisco, CA 94158 2517, USA"}]},{"given":"Noemi","family":"del-Toro","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, \u00a0Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Henning","family":"Hermjakob","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, \u00a0Hinxton, Cambridgeshire CB10 1SD, UK"}]},{"given":"Pablo","family":"Porras","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, \u00a0Hinxton, Cambridgeshire CB10 1SD, UK"}]}],"member":"286","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"2023051609021168600_btab319-B1","doi-asserted-by":"crossref","first-page":"W601","DOI":"10.1093\/nar\/gkt392","article-title":"A new reference implementation of the PSICQUIC web service","volume":"41","author":"del-Toro","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2023051609021168600_btab319-B2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"2023051609021168600_btab319-B3","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/bioinformatics\/btz835","article-title":"The cytoscape BioGateway app: explorative network building from an RDF store","volume":"36","author":"Holm\u00e5s","year":"2020","journal-title":"Bioinformatics"},{"key":"2023051609021168600_btab319-B4","doi-asserted-by":"crossref","first-page":"2002106","DOI":"10.2807\/1560-7917.ES.2020.26.1.2002106","article-title":"Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020","volume":"26","author":"Leung","year":"2021","journal-title":"Eurosurveill"},{"key":"2023051609021168600_btab319-B5","doi-asserted-by":"crossref","first-page":"D358","DOI":"10.1093\/nar\/gkt1115","article-title":"The MIntAct project\u2013IntAct as a common curation platform for 11 molecular interaction databases","volume":"42","author":"Orchard","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023051609021168600_btab319-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-19942-z","article-title":"Toward a unified open access dataset of molecular interactions","volume":"11","author":"Porras","year":"2020","journal-title":"Nat. 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