{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:38:03Z","timestamp":1769841483337,"version":"3.49.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62076082"],"award-info":[{"award-number":["62076082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000467"],"award-info":[{"award-number":["32000467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC0907503"],"award-info":[{"award-number":["2017YFC0907503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC0910504"],"award-info":[{"award-number":["2018YFC0910504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0901605"],"award-info":[{"award-number":["2016YFC0901605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Circular consensus sequencing reads are promising for the comprehensive detection of structural variants (SVs). However, alignment-based SV calling pipelines are computationally intensive due to the generation of complete read-alignments and its post-processing. Herein, we propose a SKeleton-based analysis toolkit for Structural Variation detection (SKSV). Benchmarks on real and simulated datasets demonstrate that SKSV has an order of magnitude of faster speed than state-of-the-art SV calling approaches; moreover, it achieves higher F1 scores for various types of SVs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>SKSV is available from https:\/\/github.com\/ydLiu-HIT\/SKSV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab341","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:14:13Z","timestamp":1620130453000},"page":"3647-3649","source":"Crossref","is-referenced-by-count":19,"title":["SKSV: ultrafast structural variation detection from circular consensus sequencing reads"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8385-1908","authenticated-orcid":false,"given":"Yadong","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Bioinformatics, Faculty of Computing, Harbin Institute of Technology , Harbin 150001, China"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Faculty of Computing, Harbin Institute of Technology , Harbin 150001, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-3999","authenticated-orcid":false,"given":"Junhao","family":"Su","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Faculty of Computing, Harbin Institute of Technology , Harbin 150001, China"},{"name":"Department of Computer Science, The University of Hong Kong , Hong Kong 999077, China"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Faculty of Computing, Harbin Institute of Technology , Harbin 150001, China"}]},{"given":"Tianyi","family":"Zang","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Faculty of Computing, Harbin Institute of Technology , Harbin 150001, China"}]},{"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Faculty of Computing, Harbin Institute of Technology , Harbin 150001, China"}]}],"member":"286","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"2023051609042990700_btab341-B1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/bioinformatics\/btx753","article-title":"Mapping-free variant calling using haplotype reconstruction from k-mer frequencies","volume":"34","author":"Audano","year":"2018","journal-title":"Bioinformatics"},{"key":"2023051609042990700_btab341-B2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrg.2016.49","article-title":"Coming of age: ten years of next-generation sequencing technologies","volume":"17","author":"Goodwin","year":"2016","journal-title":"Nat. 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