{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:23:52Z","timestamp":1767925432844,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hungarian Research and Developments Fund","award":["OTKA K119287"],"award-info":[{"award-number":["OTKA K119287"]}]},{"name":"Hungarian Research and Developments Fund","award":["132522"],"award-info":[{"award-number":["132522"]}]},{"DOI":"10.13039\/100004410","name":"EMBO","doi-asserted-by":"publisher","award":["STF-8784"],"award-info":[{"award-number":["STF-8784"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"EMBO","doi-asserted-by":"publisher","award":["LP2012-35"],"award-info":[{"award-number":["LP2012-35"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Momentum Grant of the Hungarian Academy of Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Cell polarity refers to the asymmetric organization of cellular components in various cells. Epithelial cells are the best-known examples of polarized cells, featuring apical and basolateral membrane domains. Mounting evidence suggests that short linear motifs play a major role in protein trafficking to these domains, although the exact rules governing them are still elusive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this study we prepared neural networks that capture recurrent patterns to classify transmembrane proteins localizing into apical and basolateral membranes. Asymmetric expression of drug transporters results in vectorial drug transport, governing the pharmacokinetics of numerous substances, yet the data on how proteins are sorted in epithelial cells is very scattered. The provided method may offer help to experimentalists to identify or better characterize molecular networks regulating the distribution of transporters or surface receptors (including viral entry receptors like that of COVID-19).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The prediction server PolarProtPred is available at http:\/\/polarprotpred.ttk.hu.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab480","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T11:09:36Z","timestamp":1624878576000},"page":"4328-4335","source":"Crossref","is-referenced-by-count":3,"title":["PolarProtPred: predicting apical and basolateral localization of transmembrane proteins using putative short linear motifs and deep learning"],"prefix":"10.1093","volume":"37","author":[{"given":"Laszlo","family":"Dobson","sequence":"first","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences , Budapest 1117, Hungary"},{"name":"Structural and Computational Biology Unit, European Molecular Biology Laboratory , Heidelberg 69117, Germany"}]},{"given":"Andr\u00e1s","family":"Zeke","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences , Budapest 1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-0285","authenticated-orcid":false,"given":"G\u00e1bor E","family":"Tusn\u00e1dy","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences , Budapest 1117, Hungary"}]}],"member":"286","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"2023061310490800700_btab480-B1","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1093\/bioinformatics\/btx431","article-title":"DeepLoc: prediction of protein subcellular localization using deep learning","volume":"33","author":"Almagro Armenteros","year":"2017","journal-title":"Bioinformatics"},{"key":"2023061310490800700_btab480-B2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks","volume":"37","author":"Armenteros","year":"2019","journal-title":"Nat. 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