{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:52:07Z","timestamp":1776052327991,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministry of Education, Youth and Sports","doi-asserted-by":"crossref","award":["LM2018131"],"award-info":[{"award-number":["LM2018131"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CZ.02.1.01\/0.0\/0.0\/16_013\/0001777"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_013\/0001777"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Secondary structures provide a deep insight into the protein architecture. They can serve for comparison between individual protein family members. The most straightforward way how to deal with protein secondary structure is its visualization using 2D diagrams. Several software tools for the generation of 2D diagrams were developed. Unfortunately, they create 2D diagrams based on only a single protein. Therefore, 2D diagrams of two proteins from one family markedly differ. For this reason, we developed the 2DProts database, which contains secondary structure 2D diagrams for all domains from the CATH and all proteins from PDB databases. These 2D diagrams are generated based on a whole protein family, and they also consider information about the 3D arrangement of secondary structure elements. Moreover, 2DProts database contains multiple 2D diagrams, which provide an overview of a whole protein family's secondary structures. 2DProts is updated weekly and is integrated into CATH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>Freely accessible at https:\/\/2dprots.ncbr.muni.cz. The web interface was implemented in JavaScript. The database was implemented in Python.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab505","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T19:13:48Z","timestamp":1625512428000},"page":"4599-4601","source":"Crossref","is-referenced-by-count":7,"title":["2DProts: database of family-wide protein secondary structure diagrams"],"prefix":"10.1093","volume":"37","author":[{"given":"Ivana","family":"Huta\u0159ov\u00e1 Va\u0159ekov\u00e1","sequence":"first","affiliation":[{"name":"National Centre for Biomolecular Research, Faculty of Science, Masaryk University , Brno 625 00, Czech Republic"},{"name":"Centre for Structural Biology, CEITEC\u2014Central European Institute of Technology, Masaryk University , Brno 625 00, Czech Republic"},{"name":"Department of Computer Systems and Communications, Faculty of Informatics, Masaryk University , Brno 602 00, Czech Republic"}]},{"given":"Jan","family":"Huta\u0159","sequence":"additional","affiliation":[{"name":"National Centre for Biomolecular Research, Faculty of Science, Masaryk University , Brno 625 00, Czech Republic"},{"name":"Centre for Structural Biology, CEITEC\u2014Central European Institute of Technology, Masaryk University , Brno 625 00, Czech Republic"}]},{"given":"Adam","family":"Midlik","sequence":"additional","affiliation":[{"name":"National Centre for Biomolecular Research, Faculty of Science, Masaryk University , Brno 625 00, Czech Republic"},{"name":"Centre for Structural Biology, CEITEC\u2014Central European Institute of Technology, Masaryk University , Brno 625 00, Czech Republic"}]},{"given":"Vladim\u00edr","family":"Horsk\u00fd","sequence":"additional","affiliation":[{"name":"National Centre for Biomolecular Research, Faculty of Science, Masaryk University , Brno 625 00, Czech Republic"},{"name":"Centre for Structural Biology, CEITEC\u2014Central European Institute of Technology, Masaryk University , Brno 625 00, Czech Republic"}]},{"given":"Eva","family":"Hladk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Computer Systems and Communications, Faculty of Informatics, Masaryk University , Brno 602 00, Czech Republic"}]},{"given":"Radka","family":"Svobodov\u00e1","sequence":"additional","affiliation":[{"name":"National Centre for Biomolecular Research, Faculty of Science, Masaryk University , Brno 625 00, Czech Republic"},{"name":"Centre for Structural Biology, CEITEC\u2014Central European Institute of Technology, Masaryk University , Brno 625 00, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-2589","authenticated-orcid":false,"given":"Karel","family":"Berka","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc , Olomouc 771 46, Czech Republic"}]}],"member":"286","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"2023061310484557400_btab505-B1","first-page":"D335","article-title":"PDBe: improved findability of macromolecular structure data in the PDB","volume":"48","author":"Armstrong","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2023061310484557400_btab505-B2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/prot.340080303","article-title":"HERA\u2014a program to draw schematic diagrams of protein secondary structures","volume":"8","author":"Hutchinson","year":"1990","journal-title":"Proteins Struct Funct Genet"},{"key":"2023061310484557400_btab505-B3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/pro.5560050204","article-title":"PROMOTIF - 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