{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:50:00Z","timestamp":1786758600866,"version":"build-2736575974"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we develop an optimal solution for this problem using dynamic programming.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability<\/jats:title>\n                    <jats:p>This is now implemented as function snp_ldsplit as part of R package bigsnpr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab519","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T23:16:28Z","timestamp":1625872588000},"page":"255-256","source":"Crossref","is-referenced-by-count":20,"title":["Optimal linkage disequilibrium splitting"],"prefix":"10.1093","volume":"38","author":[{"given":"Florian","family":"Priv\u00e9","sequence":"first","affiliation":[{"name":"National Centre for Register-Based Research, Aarhus University , Aarhus 8210, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"2023020108392148000_btab519-B1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/bioinformatics\/btv546","article-title":"Approximately independent linkage disequilibrium blocks in human populations","volume":"32","author":"Berisa","year":"2016","journal-title":"Bioinformatics"},{"key":"2023020108392148000_btab519-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-09718-5","article-title":"Polygenic prediction via bayesian regression and continuous shrinkage priors","volume":"10","author":"Ge","year":"2019","journal-title":"Nat. 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