{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:46:00Z","timestamp":1740185160560,"version":"3.37.3"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020B0101350001"],"award-info":[{"award-number":["2020B0101350001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21933004"],"award-info":[{"award-number":["21933004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Fundamental Research Program","doi-asserted-by":"publisher","award":["GXWD20201231165807007-20200812124825001"],"award-info":[{"award-number":["GXWD20201231165807007-20200812124825001"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Phosphate binding plays an important role in modulating protein\u2013protein interactions, which are ubiquitous in various biological processes. Accurate prediction of phosphate binding sites is an important but challenging task. Small size and diversity of phosphate binding sites lead to a substantial challenge for developing accurate prediction methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here, we present the phosphate binding site predictor (PBSP), a novel and accurate approach to identifying phosphate binding sites from protein structures. PBSP combines an energy-based ligand-binding sites identification method with reverse focused docking using a phosphate probe. We show that PBSP outperforms not only general ligand binding sites predictors but also other existing phospholigand-specific binding sites predictors. It achieves \u223c95% success rate for top 10 predicted sites with an average Matthews correlation coefficient value of 0.84 for successful predictions. PBSP can accurately predict phosphate binding modes, with average position error of 1.4 and 2.4\u2009\u00c5 in bound and unbound datasets, respectively. Lastly, visual inspection of the predictions is conducted. Reasons for failed predictions are further analyzed and possible ways to improve the performance are provided. These results demonstrate a novel and accurate approach to phosphate binding sites identification in protein structures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The software and benchmark datasets are freely available at http:\/\/web.pkusz.edu.cn\/wu\/PBSP\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab525","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T19:11:35Z","timestamp":1626203495000},"page":"4712-4718","source":"Crossref","is-referenced-by-count":1,"title":["Phosphate binding sites prediction in phosphorylation-dependent protein\u2013protein interactions"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-8463","authenticated-orcid":false,"given":"Zheng-Chang","family":"Lu","sequence":"first","affiliation":[{"name":"Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School , Shenzhen 518132, China"},{"name":"Shenzhen Bay Laboratory , Shenzhen 518132, China"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School , Shenzhen 518132, China"}]},{"given":"Yun-Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School , Shenzhen 518132, China"},{"name":"Shenzhen Bay Laboratory , Shenzhen 518132, China"},{"name":"College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China"}]}],"member":"286","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"2023051607133157900_btab525-B1","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1063\/1.478676","article-title":"Gaussian-3 theory using density functional geometries and zero-point energies","volume":"110","author":"Baboul","year":"1999","journal-title":"J. Chem. Phys"},{"key":"2023051607133157900_btab525-B2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/bioinformatics\/16.5.412","article-title":"Assessing the accuracy of prediction algorithms for classification: an overview","volume":"16","author":"Baldi","year":"2000","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.compbiolchem.2018.02.008","article-title":"Multiple grid arrangement improves ligand docking with unknown binding sites: application to the inverse docking problem","volume":"73","author":"Ban","year":"2018","journal-title":"Comput. Biol. Chem"},{"key":"2023051607133157900_btab525-B4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2023051607133157900_btab525-B5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/prot.20123","article-title":"Towards a structural classification of phosphate binding sites in protein-nucleotide complexes: an automated all-against-all structural comparison using geometric matching","volume":"56","author":"Brakoulias","year":"2004","journal-title":"Proteins"},{"key":"2023051607133157900_btab525-B6","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/pmic.201100563","article-title":"History of protein\u2013protein interactions: from egg-white to complex networks","volume":"12","author":"Braun","year":"2012","journal-title":"Proteomics"},{"key":"2023051607133157900_btab525-B7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2023051607133157900_btab525-B8","doi-asserted-by":"crossref","first-page":"e1000585","DOI":"10.1371\/journal.pcbi.1000585","article-title":"Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure","volume":"5","author":"Capra","year":"2009","journal-title":"PLoS Comput. Biol"},{"key":"2023051607133157900_btab525-B9","first-page":"226","volume-title":"Proceedings of the Second International Conference on Knowledge Discovery and Data Mining","author":"Ester","year":"1996"},{"year":"2016","author":"Frisch","key":"2023051607133157900_btab525-B10"},{"key":"2023051607133157900_btab525-B11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/pro.540","article-title":"Prediction of ligand-binding sites of proteins by molecular docking calculation for a random ligand library","volume":"20","author":"Fukunishi","year":"2011","journal-title":"Protein Sci"},{"key":"2023051607133157900_btab525-B12","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1093\/bioinformatics\/btp562","article-title":"EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures","volume":"25","author":"Ghersi","year":"2009","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/prot.22154","article-title":"Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites","volume":"74","author":"Ghersi","year":"2009","journal-title":"Proteins"},{"key":"2023051607133157900_btab525-B14","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/prot.24117","article-title":"Automated identification of binding sites for phosphorylated ligands in protein structures","volume":"80","author":"Ghersi","year":"2012","journal-title":"Proteins"},{"key":"2023051607133157900_btab525-B15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.pbi.2010.06.001","article-title":"Plant phosphopeptide-binding proteins as signaling mediators","volume":"13","author":"Gokirmak","year":"2010","journal-title":"Curr. Opin. Plant Biol"},{"key":"2023051607133157900_btab525-B16","doi-asserted-by":"crossref","first-page":"154104","DOI":"10.1063\/1.3382344","article-title":"A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu","volume":"132","author":"Grimme","year":"2010","journal-title":"J. Chem. Phys"},{"key":"2023051607133157900_btab525-B17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.sbi.2020.11.011","article-title":"Advances to tackle backbone flexibility in protein docking","volume":"67","author":"Harmalkar","year":"2021","journal-title":"Curr. Opin. Struct. Biol"},{"key":"2023051607133157900_btab525-B18","doi-asserted-by":"crossref","first-page":"W210","DOI":"10.1093\/nar\/gku321","article-title":"GalaxySite: ligand-binding-site prediction by using molecular docking","volume":"42","author":"Heo","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023051607133157900_btab525-B19","doi-asserted-by":"crossref","first-page":"W413","DOI":"10.1093\/nar\/gkp281","article-title":"SITEHOUND-web: a server for ligand binding site identification in protein structures","volume":"37","author":"Hernandez","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2023051607133157900_btab525-B20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/pro.618","article-title":"Toward prediction of functional protein pockets using blind docking and pocket search algorithms","volume":"20","author":"Hetenyi","year":"2011","journal-title":"Protein Sci"},{"key":"2023051607133157900_btab525-B21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/anie.200603420","article-title":"Phosphate recognition in structural biology","volume":"46","author":"Hirsch","year":"2007","journal-title":"Angew. Chem. Int. Ed. Engl"},{"key":"2023051607133157900_btab525-B22","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jcc.20634","article-title":"A semiempirical free energy force field with charge-based desolvation","volume":"28","author":"Huey","year":"2007","journal-title":"J. Comput. Chem"},{"key":"2023051607133157900_btab525-B23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tem.2015.09.013","article-title":"Protein phosphorylation: a major switch mechanism for metabolic regulation","volume":"26","author":"Humphrey","year":"2015","journal-title":"Trends Endocrinol. Metab"},{"key":"2023051607133157900_btab525-B24","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1093\/bioinformatics\/btx350","article-title":"DeepSite: protein-binding site predictor using 3D-convolutional neural networks","volume":"33","author":"Jimenez","year":"2017","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B25","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1098\/rstb.2012.0106","article-title":"Modular evolution of phosphorylation-based signalling systems","volume":"367","author":"Jin","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci"},{"key":"2023051607133157900_btab525-B26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1042\/BST0370627","article-title":"The regulation of protein phosphorylation","volume":"37","author":"Johnson","year":"2009","journal-title":"Biochem. Soc. Trans"},{"key":"2023051607133157900_btab525-B27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1110\/ps.04964705","article-title":"A computational method for the analysis and prediction of protein:phosphopeptide-binding sites","volume":"14","author":"Joughin","year":"2005","journal-title":"Protein Sci"},{"key":"2023051607133157900_btab525-B28","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1021\/acs.chemrev.5b00683","article-title":"Predicting protein\u2013protein interactions from the molecular to the proteome level","volume":"116","author":"Keskin","year":"2016","journal-title":"Chem. Rev"},{"key":"2023051607133157900_btab525-B29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/protein\/12.1.11","article-title":"Structural motif of phosphate-binding site common to various protein superfamilies: all-against-all structural comparison of protein-mononucleotide complexes","volume":"12","author":"Kinoshita","year":"1999","journal-title":"Protein Eng"},{"key":"2023051607133157900_btab525-B30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13321-018-0285-8","article-title":"P2Rank: machine learning based tool for rapid and accurate prediction of ligand binding sites from protein structure","volume":"10","author":"Krivak","year":"2018","journal-title":"J. Cheminform"},{"key":"2023051607133157900_btab525-B31","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/prot.22488","article-title":"Improved prediction of protein side-chain conformations with SCWRL4","volume":"77","author":"Krivov","year":"2009","journal-title":"Proteins"},{"key":"2023051607133157900_btab525-B32","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/bioinformatics\/bti315","article-title":"Q-SiteFinder: an energy-based method for the prediction of protein\u2013ligand binding sites","volume":"21","author":"Laurie","year":"2005","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/1471-2105-10-168","article-title":"Fpocket: an open source platform for ligand pocket detection","volume":"10","author":"Le Guilloux","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2023051607133157900_btab525-B34","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jmb.2013.11.027","article-title":"GpIbalpha interacts exclusively with exosite II of thrombin","volume":"426","author":"Lechtenberg","year":"2014","journal-title":"J. Mol. Biol"},{"key":"2023051607133157900_btab525-B35","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1021\/acs.jcim.6b00407","article-title":"MIB: metal ion-binding site prediction and docking server","volume":"56","author":"Lin","year":"2016","journal-title":"J. Chem. Inf. Model"},{"key":"2023051607133157900_btab525-B36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41401-019-0228-6","article-title":"CB-Dock: a web server for cavity detection-guided protein-ligand blind docking","volume":"41","author":"Liu","year":"2020","journal-title":"Acta Pharmacol. Sin"},{"key":"2023051607133157900_btab525-B37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.str.2009.11.012","article-title":"The structural basis of peptide\u2013protein binding strategies","volume":"18","author":"London","year":"2010","journal-title":"Structure"},{"key":"2023051607133157900_btab525-B38","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1021\/bi201092q","article-title":"Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D","volume":"50","author":"Madan","year":"2011","journal-title":"Biochemistry"},{"key":"2023051607133157900_btab525-B39","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1093\/bioinformatics\/bty355","article-title":"Efficient flexible backbone protein\u2013protein docking for challenging targets","volume":"34","author":"Marze","year":"2018","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B40","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0005-2795(75)90109-9","article-title":"Comparison of the predicted and observed secondary structure of T4 phage lysozyme","volume":"405","author":"Matthews","year":"1975","journal-title":"Biochim. Biophys. Acta (BBA) Protein Struct"},{"key":"2023051607133157900_btab525-B41","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem"},{"key":"2023051607133157900_btab525-B42","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/prot.20897","article-title":"On the nature of cavities on protein surfaces: application to the identification of drug-binding sites","volume":"63","author":"Nayal","year":"2006","journal-title":"Proteins"},{"key":"2023051607133157900_btab525-B43","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.str.2011.09.021","article-title":"Phosphorylation in protein\u2013protein binding: effect on stability and function","volume":"19","author":"Nishi","year":"2011","journal-title":"Structure"},{"key":"2023051607133157900_btab525-B44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fgene.2014.00270","article-title":"Physicochemical mechanisms of protein regulation by phosphorylation","volume":"5","author":"Nishi","year":"2014","journal-title":"Front. Genet"},{"key":"2023051607133157900_btab525-B45","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/nar\/gkq987","article-title":"Phosphate binding sites identification in protein structures","volume":"39","author":"Parca","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2023051607133157900_btab525-B46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0962-8924(01)02154-7","article-title":"SH2 domains, interaction modules and cellular wiring","volume":"11","author":"Pawson","year":"2001","journal-title":"Trends in Cell Biology"},{"key":"2023051607133157900_btab525-B47","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/jcc.1058","article-title":"6-31G basis set for third-row atoms","volume":"22","author":"Rassolov","year":"2001","journal-title":"J. Computat. Chem"},{"key":"2023051607133157900_btab525-B48","doi-asserted-by":"crossref","first-page":"e1004586","DOI":"10.1371\/journal.pcbi.1004586","article-title":"AutoDockFR: advances in protein\u2013ligand docking with explicitly specified binding site flexibility","volume":"11","author":"Ravindranath","year":"2015","journal-title":"PLoS Comput. Biol"},{"key":"2023051607133157900_btab525-B49","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1093\/bioinformatics\/btw367","article-title":"AutoSite: an automated approach for pseudo-ligands prediction-from ligand-binding sites identification to predicting key ligand atoms","volume":"32","author":"Ravindranath","year":"2016","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B50","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrm3640","article-title":"Phospho-Ser\/Thr-binding domains: navigating the cell cycle and DNA damage response","volume":"14","author":"Reinhardt","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"2023051607133157900_btab525-B51","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/prot.23174","article-title":"Assessment of ligand-binding residue predictions in CASP9","volume":"79","author":"Schmidt","year":"2011","journal-title":"Proteins"},{"key":"2023051607133157900_btab525-B52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10930-017-9696-z","article-title":"Phosphorylation: implications in cancer","volume":"36","author":"Singh","year":"2017","journal-title":"Protein J"},{"key":"2023051607133157900_btab525-B53","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/jmbi.1996.0112","article-title":"Crystal structures of the human p56lckSH2 domain in complex with two short phosphotyrosyl peptides at 1.0 \u00c5 and 1.8 \u00c5 resolution","volume":"256","author":"Tong","year":"1996","journal-title":"J. Mol. Biol"},{"key":"2023051607133157900_btab525-B54","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/bioinformatics\/btg224","article-title":"PISCES: a protein sequence culling server","volume":"19","author":"Wang","year":"2003","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B55","doi-asserted-by":"crossref","first-page":"W438","DOI":"10.1093\/nar\/gky439","article-title":"COACH-D: improved protein\u2013ligand binding sites prediction with refined ligand-binding poses through molecular docking","volume":"46","author":"Wu","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023051607133157900_btab525-B56","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/bioinformatics\/bts182","article-title":"Ligand-binding site prediction using ligand-interacting and binding site-enriched protein triangles","volume":"28","author":"Xie","year":"2012","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s41048-017-0045-8","article-title":"Docking-based inverse virtual screening: methods, applications, and challenges","volume":"4","author":"Xu","year":"2018","journal-title":"Biophys. Rep"},{"key":"2023051607133157900_btab525-B58","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1016\/S0969-2126(01)00580-9","article-title":"PhosphoSerine\/threonine binding domains: you can't pSERious?","volume":"9","author":"Yaffe","year":"2001","journal-title":"Structure"},{"key":"2023051607133157900_btab525-B59","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/bioinformatics\/btt447","article-title":"Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment","volume":"29","author":"Yang","year":"2013","journal-title":"Bioinformatics"},{"key":"2023051607133157900_btab525-B60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/bioinformatics\/btq672","article-title":"MSPocket: an orientation-independent algorithm for the detection of ligand binding pockets","volume":"27","author":"Zhu","year":"2011","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btab525\/39877985\/btab525.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/37\/24\/4712\/50334781\/btab525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/37\/24\/4712\/50334781\/btab525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:42:08Z","timestamp":1684222928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/37\/24\/4712\/6322984"}},"subtitle":[],"editor":[{"given":"Yann","family":"Ponty","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":60,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,12,11]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btab525","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"type":"print","value":"1367-4803"},{"type":"electronic","value":"1367-4811"}],"subject":[],"published-other":{"date-parts":[[2021,12,15]]},"published":{"date-parts":[[2021,7,16]]}}}