{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:04:04Z","timestamp":1768831444239,"version":"3.49.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Buchan Foundation and Schroeder Arthritis Institute via the Toronto General and Western Hospital Foundation"},{"DOI":"10.13039\/100009663","name":"University Health Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ontario Research Fund","award":["34876"],"award-info":[{"award-number":["34876"]}]},{"name":"Natural Sciences Research Council","award":["#203475"],"award-info":[{"award-number":["#203475"]}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["29272"],"award-info":[{"award-number":["29272"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["225404"],"award-info":[{"award-number":["225404"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["30865"],"award-info":[{"award-number":["30865"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004316","name":"IBM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Functional annotation is a common part of microRNA (miRNA)-related research, typically carried as pathway enrichment analysis of the selected miRNA targets. Here, we propose miRAnno, a fast and easy-to-use web application for miRNA annotation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>miRAnno uses comprehensive molecular interaction network and random walks with restart to measure the association between miRNAs and individual pathways. Independent validation shows that miRAnno achieves higher signal-to-noise ratio compared to the standard enrichment analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>miRAnno is freely available at https:\/\/ophid.utoronto.ca\/miRAnno\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab527","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T03:15:26Z","timestamp":1626491726000},"page":"592-593","source":"Crossref","is-referenced-by-count":4,"title":["miRAnno\u2014network-based functional microRNA annotation"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-0032","authenticated-orcid":false,"given":"Tomas","family":"Tokar","sequence":"first","affiliation":[{"name":"Osteoarthritis Research Program Division of Orthopedic Surgery Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"}]},{"given":"Chiara","family":"Pastrello","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program Division of Orthopedic Surgery Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"}]},{"given":"Mark","family":"Abovsky","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program Division of Orthopedic Surgery Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"}]},{"given":"Sara","family":"Rahmati","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program Division of Orthopedic Surgery Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-946X","authenticated-orcid":false,"given":"Igor","family":"Jurisica","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Program Division of Orthopedic Surgery Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"},{"name":"Departments of Medical Biophysics and Computer Science, University of Toronto , Toronto, Ontario, Canada"},{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences , Bratislava, Slovakia"}]}],"member":"286","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"2023020108412750100_btab527-B1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/bioinformatics\/btv023","article-title":"Bias in microRNA functional enrichment analysis","volume":"31","author":"Bleazard","year":"2015","journal-title":"Bioinformatics"},{"key":"2023020108412750100_btab527-B2","first-page":"1","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi","year":"2006","journal-title":"InterJ. 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