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While conventional analysis of receptor motions in the cell membrane mostly relies on the mean-squared displacement plots, much information is lost when producing these plots from the trajectories. Here we employ deep learning to classify breast cancer cell types based on the trajectories of epidermal growth factor receptor (EGFR). Our model is an artificial neural network trained on the EGFR motions acquired from six breast cancer cell lines of varying invasiveness and receptor status: MCF7 (hormone receptor positive), BT474 (HER2-positive), SKBR3 (HER2-positive), MDA-MB-468 (triple negative, TN), MDA-MB-231 (TN) and BT549 (TN).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The model successfully classified the trajectories within individual cell lines with 83% accuracy and predicted receptor status with 85% accuracy. To further validate the method, epithelial\u2013mesenchymal transition (EMT) was induced in benign MCF10A cells, noninvasive MCF7 cancer cells and highly invasive MDA-MB-231 cancer cells, and EGFR trajectories from these cells were tested. As expected, after EMT induction, both MCF10A and MCF7 cells showed higher rates of classification as TN cells, but not the MDA-MB-231 cells. Whereas deep learning-based cancer cell classifications are primarily based on the optical transmission images of cell morphology and the fluorescence images of cell organelles or cytoskeletal structures, here we demonstrated an alternative way to classify cancer cells using a dynamic, biophysical feature that is readily accessible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>A python implementation of deep learning-based classification can be found at https:\/\/github.com\/soonwoohong\/Deep-learning-for-EGFR-trajectory-classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab581","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T11:25:54Z","timestamp":1628767554000},"page":"243-249","source":"Crossref","is-referenced-by-count":10,"title":["Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics"],"prefix":"10.1093","volume":"38","author":[{"given":"Mirae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Computer Science, Rice University , Houston, TX 77005, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-9052","authenticated-orcid":false,"given":"Soonwoo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The University of Texas at Austin, TX 78712, USA"}]},{"given":"Thomas E","family":"Yankeelov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The University of Texas at Austin, TX 78712, USA"},{"name":"Oden Institute for Computational Engineering and Science, The University of Texas at Austin, TX 78712, USA"},{"name":"Department of Diagnostic Medicine, The University of Texas at Austin, TX 78712, USA"},{"name":"Department of Oncology, The University of Texas at Austin, TX 78712, USA"},{"name":"Livestrong Cancer Institutes, The University of Texas at Austin, TX 78712, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6654-5626","authenticated-orcid":false,"given":"Hsin-Chih","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The University of Texas at Austin, TX 78712, USA"},{"name":"Texas Materials Institute, The University of Texas at Austin, TX 78712, USA"}]},{"given":"Yen-Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Master Program for Biomedical Engineering, China Medical University, Taichung 40678, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University , Taichung 40678, Taiwan"}]}],"member":"286","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"2023020108393255600_btab581-B1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-5793(97)00412-2","article-title":"The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions","volume":"410","author":"Alroy","year":"1997","journal-title":"FEBS Lett"},{"key":"2023020108393255600_btab581-B2","doi-asserted-by":"crossref","first-page":"e0177544","DOI":"10.1371\/journal.pone.0177544","article-title":"Classification of breast cancer histology images using convolutional neural networks","volume":"12","author":"Ara\u00fajo","year":"2017","journal-title":"PLoS One"},{"key":"2023020108393255600_btab581-B3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10585-008-9170-6","article-title":"Epithelial mesenchymal transition traits in human breast cancer cell lines","volume":"25","author":"Blick","year":"2008","journal-title":"Clin. 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