{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:02:19Z","timestamp":1788256939301,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Spanish MINECO project Total2DChrom","award":["RTI2018-098577-B-C21"],"award-info":[{"award-number":["RTI2018-098577-B-C21"]}]},{"name":"Catalan AGAUR project","award":["2018LLAV00072"],"award-info":[{"award-number":["2018LLAV00072"]}]},{"name":"Marie Sklodowska-Curie grant","award":["798038"],"award-info":[{"award-number":["798038"]}]},{"name":"URV PMF-PIPF program","award":["2019PMF-PIPF-37"],"award-info":[{"award-number":["2019PMF-PIPF-37"]}]},{"name":"AGAUR consolidated group","award":["2017 SGR 1119"],"award-info":[{"award-number":["2017 SGR 1119"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya"},{"name":"COST Action","award":["805 CA17118"],"award-info":[{"award-number":["805 CA17118"]}]},{"DOI":"10.13039\/501100000921","name":"COST (European Cooperation in Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The combination, analysis and evaluation of different studies which try to answer or solve the same scientific question, also known as a meta-analysis, plays a crucial role in answering relevant clinical relevant questions. Unfortunately, metabolomics studies rarely disclose all the statistical information needed to perform a meta-analysis. Here, we present a meta-analysis approach using only the most reported statistical parameters in this field: P-value and fold-change. The P-values are combined via Fisher\u2019s method and fold-changes by averaging, both weighted by the study size (n). The amanida package includes several visualization options: a volcano plot for quantitative results, a vote plot for total regulation behaviours (up\/down regulations) for each compound, and a explore plot of the vote-counting results with the number of times a compound is found upregulated or downregulated. In this way, it is very easy to detect discrepancies between studies at a first glance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Amanida code and documentation are at CRAN and https:\/\/github.com\/mariallr\/amanida.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab591","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:18:07Z","timestamp":1629141487000},"page":"583-585","source":"Crossref","is-referenced-by-count":26,"title":["Amanida: an R package for meta-analysis of metabolomics non-integral data"],"prefix":"10.1093","volume":"38","author":[{"given":"Maria","family":"Llambrich","sequence":"first","affiliation":[{"name":"Department of Electrical Electronic Engineering and Automation, Universitat Rovira i Virgili, IISPV , 43007 Tarragona, Spain"},{"name":"Metabolomics Interdisciplinary Group, Department of Nutrition and Metabolism, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili , 43201 Reus, Catalonia, Spain"},{"name":"Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), ISCIII , 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eudald","family":"Correig","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Universitat Rovira i Virgili , 43201 Reus, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Gum\u00e0","sequence":"additional","affiliation":[{"name":"Oncology Department, Hospital Universitari Sant Joan de Reus, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili , 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Brezmes","sequence":"additional","affiliation":[{"name":"Department of Electrical Electronic Engineering and Automation, Universitat Rovira i Virgili, IISPV , 43007 Tarragona, Spain"},{"name":"Metabolomics Interdisciplinary Group, Department of Nutrition and Metabolism, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili , 43201 Reus, Catalonia, Spain"},{"name":"Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), ISCIII , 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Cumeras","sequence":"additional","affiliation":[{"name":"Department of Electrical Electronic Engineering and Automation, Universitat Rovira i Virgili, IISPV , 43007 Tarragona, Spain"},{"name":"Metabolomics Interdisciplinary Group, Department of Nutrition and Metabolism, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili , 43201 Reus, Catalonia, Spain"},{"name":"Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), ISCIII , 28029 Madrid, Spain"},{"name":"West Coast Metabolomics Center, University of California Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"2023020108412201300_btab591-B1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid. 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