{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T06:21:46Z","timestamp":1698992506938},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"General Program of Natural Science Foundation of China","award":["81372272"],"award-info":[{"award-number":["81372272"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Aberrant DNA methylation is strongly associated with heterogeneity in tumors. This study investigated the prognostic value of CpG island methylator phenotype in hepatocellular carcinoma (HCC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 319 HCC samples with 21 121 CpG sites were included in this study and 215 disease-free survival (DFS) and overall survival (OS)-related CpG sites were identified. These CpG sites were divided into seven clusters by using consensus clustering method. Cluster 4, which constructed the prognostic prediction model as the seed cluster to evaluate survival risk for DFS and OS of HCC patients, had the lowest methylation level with the worse prognosis. The low-risk group patients had a significantly prolonged DFS and OS than the patients in the high-risk group (P\u2009=\u20090.008 and P\u2009&amp;lt;\u20090.001, respectively). A receiver operating characteristic curve results for predicting DFS and OS were 0.691 and 0.695, respectively. These results suggested that the CpG site methylation appears to be an informative prognostic biomarker in HCC. The CpG site methylation-related prognostic model may be an innovative insight to evaluate clinical outcomes for HCC patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The code of the analysis is available at https:\/\/www.bioconductor.org.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab600","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T11:47:25Z","timestamp":1629200845000},"page":"9-15","source":"Crossref","is-referenced-by-count":1,"title":["The role of CpG island methylator phenotype in the clinical course of hepatocellular carcinoma"],"prefix":"10.1093","volume":"38","author":[{"given":"Jun","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Institute for Precision Medicine, Tsinghua University , Beijing 102218, China"},{"name":"Department of Hepatobiliary Surgery, Center of Hepatobiliary Pancreatic Disease, Xuzhou Central Hospital , Xuzhou 221000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongsong","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Center of Hepatobiliary Pancreatic Disease, Xuzhou Central Hospital , Xuzhou 221000, China"},{"name":"Xuzhou Clinical School of Xuzhou Medical University , Xuzhou 221000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Institute for Precision Medicine, Tsinghua University , Beijing 102218, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen University General Hospital , Shenzhen 518000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Institute for Precision Medicine, Tsinghua University , Beijing 102218, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Institute for Precision Medicine, Tsinghua University , Beijing 102218, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"2023020108390081200_btab600-B1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome \u2013 biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. 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