{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:24:59Z","timestamp":1774556699705,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["21-20238S"],"award-info":[{"award-number":["21-20238S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>We present the LipidQuant 1.0 tool for automated data processing workflows in lipidomic quantitation based on lipid class separation coupled with high-resolution mass spectrometry. Lipid class separation workflows, such as hydrophilic interaction liquid chromatography or supercritical fluid chromatography, should be preferred in lipidomic quantitation due to the coionization of lipid class internal standards with analytes from the same class. The individual steps in the LipidQuant workflow are explained, including lipid identification, quantitation, isotopic correction and reporting results. We show the application of LipidQuant data processing to a small cohort of human serum samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The LipidQuant 1.0 is freely available at Zenodo https:\/\/doi.org\/10.5281\/zenodo.5151201 and https:\/\/holcapek.upce.cz\/lipidquant.php.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab644","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:46:10Z","timestamp":1631101570000},"page":"4591-4592","source":"Crossref","is-referenced-by-count":14,"title":["LipidQuant 1.0: automated data processing in lipid class separation\u2013mass spectrometry quantitative workflows"],"prefix":"10.1093","volume":"37","author":[{"given":"Denise","family":"Wolrab","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]},{"given":"Eva","family":"C\u00edfkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]},{"given":"Pavel","family":"\u010c\u00e1\u0148","sequence":"additional","affiliation":[{"name":"DEZA, a.s. , Vala\u0161sk\u00e9 Mezi\u0159\u00ed\u010d\u00ed 75701, Czech Republic"}]},{"given":"Miroslav","family":"L\u00edsa","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]},{"given":"Ond\u0159ej","family":"Peterka","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]},{"given":"Michaela","family":"Chocholou\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]},{"given":"Robert","family":"Jir\u00e1sko","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]},{"given":"Michal","family":"Hol\u010dapek","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology , Pardubice 53210, Czech Republic"}]}],"member":"286","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2023061310534877800_btab644-B1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","article-title":"Update of the LIPID MAPS comprehensive classification system for lipids","volume":"50","author":"Fahy","year":"2009","journal-title":"J. Lipid Res"},{"key":"2023061310534877800_btab644-B2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/bioinformatics\/btq699","article-title":"Lipid Data Analyzer: unattended identification and quantitation of lipids in LC-MS data","volume":"27","author":"Hartler","year":"2011","journal-title":"Bioinformatics"},{"key":"2023061310534877800_btab644-B3","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1021\/acs.analchem.7b05395","article-title":"Lipidomic analysis","volume":"90","author":"Hol\u010dapek","year":"2018","journal-title":"Anal. Chem"},{"key":"2023061310534877800_btab644-B4","first-page":"217","article-title":"Software tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values","volume":"20","author":"Koelmel","year":"2019","journal-title":"Bioinformatics"},{"key":"2023061310534877800_btab644-B5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s42255-019-0094-z","article-title":"Lipidomics needs more standardization","volume":"1","author":"Liebisch","year":"2019","journal-title":"Nat. Metab"},{"key":"2023061310534877800_btab644-B6","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/s41467-020-15960-z","article-title":"LipidCreator workbench to probe the lipidomic landscape","volume":"11","author":"Peng","year":"2020","journal-title":"Nat. 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