{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:29:51Z","timestamp":1788013791729,"version":"build-2784847793"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fujian Provincial Department of Education Project-Young and Middle-aged Teacher Education Project","award":["JAT200474"],"award-info":[{"award-number":["JAT200474"]}]},{"name":"Xiamen University of Technology High-level Talent Project","award":["YKJ20020R"],"award-info":[{"award-number":["YKJ20020R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>Function-related metabolites, the terminal products of the cell regulation, show a close association with complex diseases. The identification of disease-related metabolites is critical to the diagnosis, prevention and treatment of diseases. However, most existing computational approaches build networks by calculating pairwise relationships, which is inappropriate for mining higher-order relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we presented a novel approach with hypergraph-based logistic matrix factorization, HGLMF, to predict the potential interactions between metabolites and disease. First, the molecular structures and gene associations of metabolites and the hierarchical structures and GO functional annotations of diseases were extracted to build various similarity measures of metabolites and diseases. Next, the kernel neighborhood similarity of metabolites (or diseases) was calculated according to the completed interactive network. Second, multiple networks of metabolites and diseases were fused, respectively, and the hypergraph structures of metabolites and diseases were built. Finally, a logistic matrix factorization based on hypergraph was proposed to predict potential metabolite\u2013disease interactions. In computational experiments, HGLMF accurately predicted the metabolite\u2013disease interaction, and performed better than other state-of-the-art methods. Moreover, HGLMF could be used to predict new metabolites (or diseases). As suggested from the case studies, the proposed method could discover novel disease-related metabolites, which has been confirmed in existing studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The codes and dataset are available at: https:\/\/github.com\/Mayingjun20179\/HGLMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab652","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:46:10Z","timestamp":1631101570000},"page":"435-443","source":"Crossref","is-referenced-by-count":32,"title":["Hypergraph-based logistic matrix factorization for metabolite\u2013disease interaction prediction"],"prefix":"10.1093","volume":"38","author":[{"given":"Yingjun","family":"Ma","sequence":"first","affiliation":[{"name":"School of Applied Mathematics, Xiamen University of Technology , Xiamen 361024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Computer & Information Engineering, Anyang Normal University , Anyang 455000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"2023020108450327400_btab652-B1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s12859-017-1845-z","article-title":"VB-MK-LMF: fusion of drugs, targets and interactions using variational Bayesian multiple kernel logistic matrix factorization","volume":"18","author":"Bolgar","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"2023020108450327400_btab652-B2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11888-018-0420-y","article-title":"Colorectal cancer and metabolism","volume":"14","author":"Brown","year":"2018","journal-title":"Curr. 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