{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T07:44:07Z","timestamp":1774770247690,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Mian is a web application to interactively visualize, run statistical tools and train machine learning models on operational taxonomic unit (OTU) or amplicon sequence variant (ASV) datasets to identify key taxonomic groups, diversity trends or taxonomic composition shifts in the context of provided categorical or numerical sample metadata. Tools, including Fisher\u2019s exact test, Boruta feature selection, alpha and beta diversity, and random forest and deep neural network classifiers, facilitate open-ended data exploration and hypothesis generation on microbial datasets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability<\/jats:title>\n                  <jats:p>Mian is freely available at: miandata.org. Mian is an open-source platform licensed under the MIT license with source code available at github.com\/tbj128\/mian.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab754","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T12:23:59Z","timestamp":1636115039000},"page":"1176-1178","source":"Crossref","is-referenced-by-count":18,"title":["Mian: interactive web-based microbiome data table visualization and machine learning platform"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4810-5816","authenticated-orcid":false,"given":"Boyang Tom","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Computer Science, Stanford University , Stanford, CA, USA 94305"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver, BC, Canada V6Z1Y6"}]},{"given":"Raymond T","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of British Columbia , Vancouver, BC, Canada V6T1Z4"}]},{"given":"James C","family":"Hogg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver, BC, Canada V6Z1Y6"}]}],"member":"286","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"2023020108511727600_btab754-B1","doi-asserted-by":"crossref","first-page":"W88","DOI":"10.1093\/nar\/gks497","article-title":"METAGENassist: A comprehensive web server for comparative metagenomics","volume":"40","author":"Arndt","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2023020108511727600_btab754-B2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. 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