{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:10Z","timestamp":1772138050144,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Programme under the PerMedCoE Project","award":["951773"],"award-info":[{"award-number":["951773"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany\u2019s Excellence","award":["Strategy\u2013EXC-2048\/1\u2013project ID 390686111"],"award-info":[{"award-number":["Strategy\u2013EXC-2048\/1\u2013project ID 390686111"]}]},{"name":"EU\u2019s Horizon 2020 research and innovation program","award":["862087"],"award-info":[{"award-number":["862087"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>COBREXA.jl is a Julia package for scalable, high-performance constraint-based reconstruction and analysis of very large-scale biological models. Its primary purpose is to facilitate the integration of modern high performance computing environments with the processing and analysis of large-scale metabolic models of challenging complexity. We report the architecture of the package, and demonstrate how the design promotes analysis scalability on several use-cases with multi-organism community models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>https:\/\/doi.org\/10.17881\/ZKCR-BT30.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab782","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:31:17Z","timestamp":1636529477000},"page":"1171-1172","source":"Crossref","is-referenced-by-count":11,"title":["COBREXA.jl: constraint-based reconstruction and exascale analysis"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-4075","authenticated-orcid":false,"given":"Miroslav","family":"Kratochv\u00edl","sequence":"first","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-0037","authenticated-orcid":false,"given":"Laurent","family":"Heirendt","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"},{"name":"ELIXIR Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]},{"given":"St Elmo","family":"Wilken","sequence":"additional","affiliation":[{"name":"Institute of Quantitative and Theoretical Biology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf , 40225 D\u00fcsseldorf, Germany"}]},{"given":"Taneli","family":"Pusa","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"},{"name":"Nium S.\u00e0.r.l. , L-4362 Esch-sur-Alzette, Luxembourg"}]},{"given":"Sylvain","family":"Arreckx","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]},{"given":"Alberto","family":"Noronha","sequence":"additional","affiliation":[{"name":"Nium S.\u00e0.r.l. , L-4362 Esch-sur-Alzette, Luxembourg"}]},{"given":"Marvin","family":"van Aalst","sequence":"additional","affiliation":[{"name":"Institute of Quantitative and Theoretical Biology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf , 40225 D\u00fcsseldorf, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-5880","authenticated-orcid":false,"given":"Venkata P","family":"Satagopam","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"},{"name":"ELIXIR Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-7398","authenticated-orcid":false,"given":"Oliver","family":"Ebenh\u00f6h","sequence":"additional","affiliation":[{"name":"Institute of Quantitative and Theoretical Biology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf , 40225 D\u00fcsseldorf, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-1618","authenticated-orcid":false,"given":"Reinhard","family":"Schneider","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"},{"name":"ELIXIR Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-6810","authenticated-orcid":false,"given":"Christophe","family":"Trefois","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"},{"name":"ELIXIR Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-6680","authenticated-orcid":false,"given":"Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"},{"name":"ELIXIR Luxembourg, Campus Belval , L-4367 Belvaux, Luxembourg"}]}],"member":"286","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"2023020108523114300_btab782-B1","doi-asserted-by":"crossref","first-page":"e1389672","DOI":"10.1080\/23723556.2017.1389672","article-title":"COBRA methods and metabolic drug targets in cancer","volume":"5","author":"Apaolaza","year":"2018","journal-title":"Mol. 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