{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:10:16Z","timestamp":1783570216393,"version":"3.55.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Engineering Research Council of Canada (NSERC) Discovery","award":["RGPIN-2016-05017"],"award-info":[{"award-number":["RGPIN-2016-05017"]}]},{"name":"National Science and Engineering Research Council of Canada (NSERC) Discovery","award":["#RGPIN-2019-05350"],"award-info":[{"award-number":["#RGPIN-2019-05350"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Drug repurposing is a potential alternative to the traditional drug discovery process. Drug repurposing can be formulated as a recommender system that recommends novel indications for available drugs based on known drug-disease associations. This article presents a method based on non-negative matrix factorization (NMF-DR) to predict the drug-related candidate disease indications. This work proposes a recommender system-based method for drug repurposing to predict novel drug indications by integrating drug and diseases related data sources. For this purpose, this framework first integrates two types of disease similarities, the associations between drugs and diseases, and the various similarities between drugs from different views to make a heterogeneous drug\u2013disease interaction network. Then, an improved non-negative matrix factorization-based method is proposed to complete the drug\u2013disease adjacency matrix with predicted scores for unknown drug\u2013disease pairs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The comprehensive experimental results show that NMF-DR achieves superior prediction performance when compared with several existing methods for drug\u2013disease association prediction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The program is available at https:\/\/github.com\/sshaghayeghs\/NMF-DR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btab826","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T20:22:18Z","timestamp":1638390138000},"page":"1369-1377","source":"Crossref","is-referenced-by-count":46,"title":["A network-based drug repurposing method via non-negative matrix factorization"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-1558","authenticated-orcid":false,"given":"Shaghayegh","family":"Sadeghi","sequence":"first","affiliation":[{"name":"School of Computer Science, University of Windsor, 401 Sunset Avenue, N9B 3P4, Windsor, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Computer Science, University of Windsor, 401 Sunset Avenue, N9B 3P4, Windsor, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alioune","family":"Ngom","sequence":"additional","affiliation":[{"name":"School of Computer Science, University of Windsor, 401 Sunset Avenue, N9B 3P4, Windsor, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"2023020108550755400_btab826-B1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.semcancer.2019.09.012","article-title":"Drug repurposing for breast cancer therapy: old weapon for new battle","volume":"68","author":"Aggarwal","year":"2021","journal-title":"Semin. 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