{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:20Z","timestamp":1740185120163,"version":"3.37.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"publisher","award":["U01 HL119178"],"award-info":[{"award-number":["U01 HL119178"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["5R01HD086911-02"],"award-info":[{"award-number":["5R01HD086911-02"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR000126","TR002015"],"award-info":[{"award-number":["KL2 TR000126","TR002015"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>The collection of temporal or perturbed data is often a prerequisite for reconstructing dynamic networks in most cases. However, these types of data are seldom available for genomic studies in medicine, thus significantly limiting the use of dynamic networks to characterize the biological principles underlying human health and diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We proposed a statistical framework to recover disease risk-associated pseudo-dynamic networks (DRDNet) from steady-state data. We incorporated a varying coefficient model with multiple ordinary differential equations to learn a series of networks. We analyzed the publicly available Genotype-Tissue Expression data to construct networks associated with hypertension risk, and biological findings showed that key genes constituting these networks had pivotal and biologically relevant roles associated with the vascular system. We also provided the selection consistency of the proposed learning procedure and evaluated its utility through extensive simulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>DRDNet is implemented in the R language, and the source codes are available at https:\/\/github.com\/chencxxy28\/DRDnet\/.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac038","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T20:12:07Z","timestamp":1645819927000},"page":"2481-2487","source":"Crossref","is-referenced-by-count":1,"title":["A statistical framework for recovering pseudo-dynamic networks from static data"],"prefix":"10.1093","volume":"38","author":[{"given":"Chixiang","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, University of Maryland School of Medicine , Baltimore, MD 21201, USA"},{"name":"Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biyi","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, College of Medicine, Pennsylvania State University , Hershey, PA 17033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3605-0811","authenticated-orcid":false,"given":"Tianzhou","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland , College Park, MD 20740, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, College of Medicine, Pennsylvania State University , Hershey, PA 17033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-6421","authenticated-orcid":false,"given":"Rongling","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, College of Medicine, Pennsylvania State University , Hershey, PA 17033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"2023041402560527100_","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The pathophysiology of cigarette smoking and cardiovascular disease: an update","volume":"43","author":"Ambrose","year":"2004","journal-title":"J. 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