{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:18:56Z","timestamp":1775312336507,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62131004"],"award-info":[{"award-number":["62131004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61922020"],"award-info":[{"award-number":["61922020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61872114"],"award-info":[{"award-number":["61872114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Provincial Science Fund for Distinguished Young Scholars","award":["2021JDJQ0025"],"award-info":[{"award-number":["2021JDJQ0025"]}]},{"name":"Special Science Foundation of Quzhou","award":["2021D004"],"award-info":[{"award-number":["2021D004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>With the analysis of the characteristic and function of circular RNAs (circRNAs), people have realized that they play a critical role in the diseases. Exploring the relationship between circRNAs and diseases is of far-reaching significance for searching the etiopathogenesis and treatment of diseases. Nevertheless, it is inefficient to learn new associations only through biotechnology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Consequently, we present a computational method, GMNN2CD, which employs a graph Markov neural network (GMNN) algorithm to predict unknown circRNA\u2013disease associations. First, used verified associations, we calculate semantic similarity and Gaussian interactive profile kernel similarity (GIPs) of the disease and the GIPs of circRNA and then merge them to form a unified descriptor. After that, GMNN2CD uses a fusion feature variational map autoencoder to learn deep features and uses a label propagation map autoencoder to propagate tags based on known associations. Based on variational inference, GMNN alternate training enhances the ability of GMNN2CD to obtain high-efficiency high-dimensional features from low-dimensional representations. Finally, 5-fold cross-validation of five benchmark datasets shows that GMNN2CD is superior to the state-of-the-art methods. Furthermore, case studies have shown that GMNN2CD can detect potential associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The source code and data are available at https:\/\/github.com\/nmt315320\/GMNN2CD.git.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac079","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T12:37:39Z","timestamp":1644410259000},"page":"2246-2253","source":"Crossref","is-referenced-by-count":92,"title":["GMNN2CD: identification of circRNA\u2013disease associations based on variational inference and graph Markov neural networks"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-4649","authenticated-orcid":false,"given":"Mengting","family":"Niu","sequence":"first","affiliation":[{"name":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China , Chengdu, Sichuan 610000, China"},{"name":"Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China , Quzhou, Zhejiang 324000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-1142","authenticated-orcid":false,"given":"Quan","family":"Zou","sequence":"additional","affiliation":[{"name":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China , Chengdu, Sichuan 610000, China"},{"name":"Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China , Quzhou, Zhejiang 324000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-9920","authenticated-orcid":false,"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Computing, Harbin Institute of Technology , Harbin, Heilongjiang 150000, China"}]}],"member":"286","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"2023020109023762500_btac079-B1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/15476286.2017.1279788","article-title":"Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1","volume":"14","author":"Abdelmohsen","year":"2017","journal-title":"RNA Biol"},{"key":"2023020109023762500_btac079-B2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/ijms19020480","article-title":"CircSMARCA5 inhibits migration of glioblastoma multiforme cells by regulating a molecular axis involving splicing factors SRSF1\/SRSF3\/PTB","volume":"19","author":"Barbagallo","year":"2018","journal-title":"Int. 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