{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:49:05Z","timestamp":1786625345800,"version":"3.56.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170651"],"award-info":[{"award-number":["32170651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072293"],"award-info":[{"award-number":["82072293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2020JJ3006"],"award-info":[{"award-number":["2020JJ3006"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Plan for Scientific Research and Development of China","award":["2016YFD0500300"],"award-info":[{"award-number":["2016YFD0500300"]}]},{"name":"Key Research and Development Program of Hunan Province","award":["2020SK2054"],"award-info":[{"award-number":["2020SK2054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Viruses continue to threaten human health. Yet, the complete viral species carried by humans and their infection characteristics have not been fully revealed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study curated an atlas of human viruses from public databases and literature, and built the Human Virus Database (HVD). The HVD contains 1131 virus species of 54 viral families which were more than twice the number of the human-infecting virus species reported in previous studies. These viruses were identified in human samples including 68 human tissues, the excreta and body fluid. The viral diversity in humans was age-dependent with a peak in the infant and a valley in the teenager. The tissue tropism of viruses was found to be associated with several factors including the viral group (DNA, RNA or reverse-transcribing viruses), enveloped or not, viral genome length and GC content, viral receptors and the virus-interacting proteins. Finally, the tissue tropism of DNA viruses was predicted using a random-forest algorithm with a middle performance. Overall, the study not only provides a valuable resource for further studies of human viruses but also deepens our understanding toward the diversity and tissue tropism of human viruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The HVD is available at http:\/\/computationalbiology.cn\/humanVirusBase\/#\/.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac275","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T07:10:15Z","timestamp":1649920215000},"page":"3087-3093","source":"Crossref","is-referenced-by-count":29,"title":["An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses"],"prefix":"10.1093","volume":"38","author":[{"given":"Sifan","family":"Ye","sequence":"first","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Qiu","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Ge","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100005, China"},{"name":"Suzhou Institute of Systems Medicine , Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanxian","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Hunan Key Laboratory of Animal Models for Human Diseases and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taijiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100005, China"},{"name":"Suzhou Institute of Systems Medicine , Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-9506","authenticated-orcid":false,"given":"Yousong","family":"Peng","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"2023041403080563500_","doi-asserted-by":"crossref","first-page":"D41","DOI":"10.1093\/nar\/gkx1094","article-title":"GenBank","volume":"46","author":"Benson","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023041403080563500_","doi-asserted-by":"crossref","first-page":"180015","DOI":"10.1038\/sdata.2018.15","article-title":"ImmPort, toward repurposing of open access immunological assay data for translational and clinical research","volume":"5","author":"Bhattacharya","year":"2018","journal-title":"Sci. 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