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Nearly one-third of known protein structures contain metal ions that are used for a variety of needs, such as catalysis, DNA\/RNA binding, protein structure stability, etc. Identifying metal-binding proteins is thus crucial for understanding the mechanisms of cellular activity. However, experimental annotation of protein metal-binding potential is severely lacking, while computational techniques are often imprecise and of limited applicability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>we developed a novel machine learning-based method, mebipred, for identifying metal-binding proteins from sequence-derived features. This method is over 80% accurate in recognizing proteins that bind metal ion-containing ligands; the specific identity of 11 ubiquitously present metal ions can also be annotated. mebipred is reference-free, i.e. no sequence alignments are involved, and is thus faster than alignment-based methods; it is also more accurate than other sequence-based prediction methods. Additionally, mebipred can identify protein metal-binding capabilities from short sequence stretches, e.g. translated sequencing reads, and, thus, may be useful for the annotation of metal requirements of metagenomic samples. We performed an analysis of available microbiome data and found that ocean, hot spring sediments and soil microbiomes use a more diverse set of metals than human host-related ones. For human microbiomes, physiological conditions explain the observed metal preferences. Similarly, subtle changes in ocean sample ion concentration affect the abundance of relevant metal-binding proteins. These results highlight mebipred\u2019s utility in analyzing microbiome metal requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>mebipred is available as a web server at services.bromberglab.org\/mebipred and as a standalone package at https:\/\/pypi.org\/project\/mymetal\/.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac358","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T15:42:38Z","timestamp":1654011758000},"page":"3532-3540","source":"Crossref","is-referenced-by-count":50,"title":["<i>mebipred<\/i>\n                    : identifying metal-binding potential in protein sequence"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-4372","authenticated-orcid":false,"given":"A A","family":"Aptekmann","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Microbiology, Rutgers University , New Brunswick, NJ 08873, USA"},{"name":"Institute of Marine and Coastal Sciences, Rutgers University , New Brunswick, NJ 08901, USA"}]},{"given":"J","family":"Buongiorno","sequence":"additional","affiliation":[{"name":"Division of Natural Sciences, Maryville College, Maryville, TN 37804, USA"}]},{"given":"D","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Institute of Marine and Coastal Sciences, Rutgers University , New Brunswick, NJ 08901, USA"},{"name":"Department of Biology, University of Naples Federico II , Naples, Italy"},{"name":"Institute for Marine Biological Resources and Biotechnology\u2014IRBIM, National Research Council of Italy, CNR , Ancona, Italy"}]},{"given":"M","family":"Glamoclija","sequence":"additional","affiliation":[{"name":"Department of Earth and Environmental Sciences, Rutgers University , Newark, NJ 07102, USA"}]},{"given":"D U","family":"Ferreiro","sequence":"additional","affiliation":[{"name":"Protein Physiology Lab, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET-IQUIBICEN , 1428 Buenos Aires, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-0844","authenticated-orcid":false,"given":"Y","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Rutgers University , New Brunswick, NJ 08873, USA"}]}],"member":"286","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"2023041405370299900_","first-page":"265","author":"Abadi","year":"2016"},{"key":"2023041405370299900_","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. 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