{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:45:20Z","timestamp":1772999120161,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Luxembourg Institute of Health and Fonds National de la Recherche","award":["ECCB2022"],"award-info":[{"award-number":["ECCB2022"]}]},{"name":"Add-on Fellowship for Interdisciplinary Life Sciences of the Joachim Herz Stiftung"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG RE3474\/2-2"],"award-info":[{"award-number":["DFG RE3474\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hasso Plattner Institute\u2019s Research School on Data Science and Engineering"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>While it has been well established that drugs affect and help patients differently, personalized drug response predictions remain challenging. Solutions based on single omics measurements have been proposed, and networks provide means to incorporate molecular interactions into reasoning. However, how to integrate the wealth of information contained in multiple omics layers still poses a complex problem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We present DrDimont, Drug response prediction from Differential analysis of multi-omics networks. It allows for comparative conclusions between two conditions and translates them into differential drug response predictions. DrDimont focuses on molecular interactions. It establishes condition-specific networks from correlation within an omics layer that are then reduced and combined into heterogeneous, multi-omics molecular networks. A novel semi-local, path-based integration step ensures integrative conclusions. Differential predictions are derived from comparing the condition-specific integrated networks. DrDimont\u2019s predictions are explainable, i.e. molecular differences that are the source of high differential drug scores can be retrieved. We predict differential drug response in breast cancer using transcriptomics, proteomics, phosphosite and metabolomics measurements and contrast estrogen receptor positive and receptor negative patients. DrDimont performs better than drug prediction based on differential protein expression or PageRank when evaluating it on ground truth data from cancer cell lines. We find proteomic and phosphosite layers to carry most information for distinguishing drug response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>DrDimont is available on CRAN: https:\/\/cran.r-project.org\/package=DrDimont.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac477","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T13:52:21Z","timestamp":1661349141000},"page":"ii113-ii119","source":"Crossref","is-referenced-by-count":4,"title":["DrDimont: explainable drug response prediction from differential analysis of multi-omics networks"],"prefix":"10.1093","volume":"38","author":[{"given":"Pauline","family":"Hiort","sequence":"first","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Hugo","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus","family":"Zeinert","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataniel","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spoorthi","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagath C","family":"Rajapakse","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Nanyang Technological University , Singapore 639798, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Azuaje","sequence":"additional","affiliation":[{"name":"Genomics England , London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard Y","family":"Renard","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Baum","sequence":"additional","affiliation":[{"name":"Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam , Potsdam 14482, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"2023041408001316200_","doi-asserted-by":"crossref","first-page":"e8124","DOI":"10.15252\/msb.20178124","article-title":"Multi-omics factor analysis\u2014a framework for unsupervised integration of multi-omics data sets","volume":"14","author":"Argelaguet","year":"2018","journal-title":"Mol. 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