{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:19:01Z","timestamp":1785928741476,"version":"3.56.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>RNA molecules are implicated in numerous fundamental biological processes and many human pathologies, such as cancer, neurodegenerative disorders, muscular diseases and bacterial infections. Modulating the mode of action of disease-implicated RNA molecules can lead to the discovery of new therapeutical agents and even address pathologies linked to \u2018undruggable\u2019 protein targets. This modulation can be achieved by direct targeting of RNA with small molecules. As of today, only a few RNA-targeting small molecules are used clinically. One of the main obstacles that have hampered the development of a rational drug design protocol to target RNA with small molecules is the lack of a comprehensive understanding of the molecular mechanisms at the basis of RNA-small molecule (RNA-SM) recognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we present Harnessing RIBOnucleic acid\u2014Small molecule Structures (HARIBOSS), a curated collection of RNA-SM structures determined by X-ray crystallography, nuclear magnetic resonance spectroscopy and cryo-electron microscopy. HARIBOSS facilitates the exploration of drug-like compounds known to bind RNA, the analysis of ligands and pockets properties and ultimately the development of in silico strategies to identify RNA-targeting small molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>HARIBOSS can be explored via a web interface available at http:\/\/hariboss.pasteur.cloud.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac483","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:47:44Z","timestamp":1657241264000},"page":"4185-4193","source":"Crossref","is-referenced-by-count":62,"title":["HARIBOSS: a curated database of RNA-small molecules structures to aid rational drug design"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-9126","authenticated-orcid":false,"given":"F P","family":"Panei","sequence":"first","affiliation":[{"name":"Sanofi, R&D, Data & In Silico Sciences , 91385 Chilly Mazarin, France"},{"name":"Department of Structural Biology and Chemistry, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 3528 , 75015 Paris, France"},{"name":"Ecole Doctorale Complexit\u00e9 du Vivant, Sorbonne Universit\u00e9 , 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-5566","authenticated-orcid":false,"given":"R","family":"Torchet","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Bioinformatics and Biostatistics Hub , F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-1009","authenticated-orcid":false,"given":"H","family":"M\u00e9nager","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Bioinformatics and Biostatistics Hub , F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-3539","authenticated-orcid":false,"given":"P","family":"Gkeka","sequence":"additional","affiliation":[{"name":"Sanofi, R&D, Data & In Silico Sciences , 91385 Chilly Mazarin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-0004","authenticated-orcid":false,"given":"M","family":"Bonomi","sequence":"additional","affiliation":[{"name":"Department of Structural Biology and Chemistry, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 3528 , 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1039\/c002418j","article-title":"Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex","volume":"8","author":"Bugaut","year":"2010","journal-title":"Org. Biomol. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/nyas.14713","article-title":"Noncoding RNAs: biology and applications-a keystone symposia report","volume":"1506","author":"Cable","year":"2021","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","article-title":"The noncoding RNA revolution-trashing old rules to forge new ones","volume":"157","author":"Cech","year":"2014","journal-title":"Cell"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1093\/bioinformatics\/btp163","article-title":"Biopython: freely available Python tools for computational molecular biology and bioinformatics","volume":"25","author":"Cock","year":"2009","journal-title":"Bioinformatics"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"628137","DOI":"10.3389\/fbioe.2021.628137","article-title":"The limitless future of RNA therapeutics","volume":"9","author":"Damase","year":"2021","journal-title":"Front. Bioeng. Biotechnol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.tips.2020.08.004","article-title":"Paving the road for RNA therapeutics","volume":"41","author":"Dammes","year":"2020","journal-title":"Trends Pharmacol. Sci"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1021\/jacs.8b13419","article-title":"Targeting RNA with small molecules to capture opportunities at the intersection of chemistry, biology, and medicine","volume":"141","author":"Disney","year":"2019","journal-title":"J. Am. Chem. Soc"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/acschembio.6b00001","article-title":"Inforna 2.0: a platform for the sequence-based design of small molecules targeting structured RNAs","volume":"11","author":"Disney","year":"2016","journal-title":"ACS Chem. Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1093\/nar\/gkaa585","article-title":"Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans","volume":"48","author":"Donlic","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"e1005659","DOI":"10.1371\/journal.pcbi.1005659","article-title":"OpenMM 7: rapid development of high performance algorithms for molecular dynamics","volume":"13","author":"Eastman","year":"2017","journal-title":"PLoS Comput. Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1039\/D0CS01261K","article-title":"Targeting RNA with small molecules: from fundamental principles towards the clinic","volume":"50","author":"Falese","year":"2021","journal-title":"Chem. Soc. Rev"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1093\/bioinformatics\/bts565","article-title":"CD-HIT: accelerated for clustering the next-generation sequencing data","volume":"28","author":"Fu","year":"2012","journal-title":"Bioinformatics"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41580-019-0136-0","article-title":"The roles of structural dynamics in the cellular functions of RNAs","volume":"20","author":"Ganser","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1747-0285.2007.00483.x","article-title":"New method for fast and accurate binding-site identification and analysis","volume":"69","author":"Halgren","year":"2007","journal-title":"Chem. Biol. Drug Des"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/ci800324m","article-title":"Identifying and characterizing binding sites and assessing druggability","volume":"49","author":"Halgren","year":"2009","journal-title":"J. Chem. Inf. Model"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1177\/2472555220922802","article-title":"Target-directed approaches for screening small molecules against RNA targets","volume":"25","author":"Haniff","year":"2020","journal-title":"SLAS Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41557-020-0514-4","article-title":"Design of a small molecule that stimulates vascular endothelial growth factor a enabled by screening RNA fold-small molecule interactions","volume":"12","author":"Haniff","year":"2020","journal-title":"Nat. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/acs.jctc.5b00864","article-title":"OPLS3: a force field providing broad coverage of drug-like small molecules and proteins","volume":"12","author":"Harder","year":"2016","journal-title":"J. Chem. Theory Comput"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"14744","DOI":"10.1039\/D0CC06796B","article-title":"Small molecule-RNA targeting: starting with the fundamentals","volume":"56","author":"Hargrove","year":"2020","journal-title":"Chem. Commun. (Camb.)"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2147\/DDDT.S164515","article-title":"Linezolid: a review of its properties, function, and use in critical care","volume":"12","author":"Hashemian","year":"2018","journal-title":"Drug Des. Devel. Ther"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.bmc.2019.04.010","article-title":"Evidence for ligandable sites in structured RNA throughout the Protein Data Bank","volume":"27","author":"Hewitt","year":"2019","journal-title":"Bioorg. Med. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nature15542","article-title":"Selective small-molecule inhibition of an RNA structural element","volume":"526","author":"Howe","year":"2015","journal-title":"Nature"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13073-017-0450-0","article-title":"Advances in the delivery of RNA therapeutics: from concept to clinical reality","volume":"9","author":"Kaczmarek","year":"2017","journal-title":"Genome Med"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd3625","article-title":"RNA therapeutics: beyond RNA interference and antisense oligonucleotides","volume":"11","author":"Kole","year":"2012","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/bioinformatics\/btu626","article-title":"PDB-wide collection of binding data: current status of the PDBbind database","volume":"31","author":"Liu","year":"2015","journal-title":"Bioinformatics"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/j.chempr.2021.05.021","article-title":"Computer-aided design of RNA-targeted small molecules: a growing need in drug discovery","volume":"7","author":"Manigrasso","year":"2021","journal-title":"Chem-US"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"D132","DOI":"10.1093\/nar\/gkt976","article-title":"SMMRNA: a database of small molecule modulators of RNA","volume":"42","author":"Mehta","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J. Comput. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"D486","DOI":"10.1093\/nar\/gkx1070","article-title":"PDBe: towards reusable data delivery infrastructure at protein data bank in Europe","volume":"46","author":"Mir","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"baw002","DOI":"10.1093\/database\/baw002","article-title":"NALDB: nucleic acid ligand database for small molecules targeting nucleic acid","volume":"2016","author":"Mishra","year":"2016","journal-title":"Database"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1021\/acs.jcim.9b00103","article-title":"mkgridXf: consistent identification of plausible binding sites despite the elusive nature of cavities and grooves in protein dynamics","volume":"59","author":"Monet","year":"2019","journal-title":"J. Chem. Inf. Model"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1002\/anie.201707641","article-title":"Discovery of key physicochemical, structural, and spatial properties of RNA-targeted bioactive ligands","volume":"56","author":"Morgan","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1021\/acschembio.9b00631","article-title":"R-BIND: an interactive database for exploring and developing RNA targeted chemical probes","volume":"14","author":"Morgan","year":"2019","journal-title":"ACS Chem. Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrg3681","article-title":"Insights into RNA structure and function from genome-wide studies","volume":"15","author":"Mortimer","year":"2014","journal-title":"Nat. Rev. Genet"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions","volume":"7","author":"Olsson","year":"2011","journal-title":"J. Chem. Theory Comput"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1039\/D0MD00167H","article-title":"Systematic analysis of the interactions driving small molecule-RNA recognition","volume":"11","author":"Padroni","year":"2020","journal-title":"RSC Med. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.jcim.7b00425","article-title":"SmilesDrawer: parsing and drawing SMILES-Encoded molecular structures using Client-Side JavaScript","volume":"58","author":"Probst","year":"2018","journal-title":"J. Chem. Inf. Model"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13321-020-0416-x","article-title":"Visualization of very large high-dimensional data sets as minimum spanning trees","volume":"12","author":"Probst","year":"2020","journal-title":"J. Cheminform"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1021\/acs.jmedchem.8b00741","article-title":"Discovery of risdiplam, a selective survival of motor neuron-2 (SMN2) gene splicing modifier for the treatment of spinal muscular atrophy (SMA)","volume":"61","author":"Ratni","year":"2018","journal-title":"J. Med. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1021\/acs.jcim.1c00155","article-title":"DrugPred_RNA-A tool for structure-based druggability predictions for RNA binding sites","volume":"61","author":"Rekand","year":"2021","journal-title":"J. Chem. Inf. Model"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/2472555219885373","article-title":"Targeting RNA with small molecules: identification of selective, RNA-Binding small molecules occupying drug-like chemical space","volume":"25","author":"Rizvi","year":"2020","journal-title":"SLAS Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1016\/j.bmcl.2017.10.052","article-title":"RNA as a small molecule druggable target","volume":"27","author":"Rizvi","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41573-020-0075-7","article-title":"Advances in oligonucleotide drug delivery","volume":"19","author":"Roberts","year":"2020","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1093\/bioinformatics\/bty419","article-title":"NGL viewer: web-based molecular graphics for large complexes","volume":"34","author":"Rose","year":"2018","journal-title":"Bioinformatics"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nchembio.2251","article-title":"Precise small-molecule recognition of a toxic CUG RNA repeat expansion","volume":"13","author":"Rzuczek","year":"2017","journal-title":"Nat. Chem. Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J. Comput. Aided Mol. Des"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1042\/EBC20200011","article-title":"Targeting RNA structures in diseases with small molecules","volume":"64","author":"Shao","year":"2020","journal-title":"Essays Biochem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"e1008309","DOI":"10.1371\/journal.pcbi.1008309","article-title":"AnnapuRNA: a scoring function for predicting RNA-small molecule binding poses","volume":"17","author":"Stefaniak","year":"2021","journal-title":"PLoS Comput. Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nchembio.596","article-title":"Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble","volume":"7","author":"Stelzer","year":"2011","journal-title":"Nat. Chem. Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1261\/rna.078889.121","article-title":"RNALigands: a database and web server for RNA-ligand interactions","volume":"28","author":"Sun","year":"2022","journal-title":"RNA"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/bioinformatics\/btaa1091","article-title":"The iPPI-DB initiative: a community-centered database of protein-protein interaction modulators","volume":"37","author":"Torchet","year":"2021","journal-title":"Bioinformatics"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.7717\/peerj.453","article-title":"Scikit-image: image processing in python","volume":"2","author":"van der Walt","year":"2014","journal-title":"PeerJ"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/d41573-020-00078-0","article-title":"RNA therapeutics on the rise","volume":"19","author":"Wang","year":"2020","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrd.2018.93","article-title":"Principles for targeting RNA with drug-like small molecules","volume":"17","author":"Warner","year":"2018","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA therapeutics\u2014challenges and potential solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41556-019-0311-8","article-title":"Cellular functions of long noncoding RNAs","volume":"21","author":"Yao","year":"2019","journal-title":"Nat. Cell Biol"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1124\/pr.120.019554","article-title":"RNA drugs and RNA targets for small molecules: principles, progress, and challenges","volume":"72","author":"Yu","year":"2020","journal-title":"Pharmacol. Rev"},{"key":"2023041408423057400_","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12859-021-04349-4","article-title":"RPocket: an intuitive database of RNA pocket topology information with RNA-ligand data resources","volume":"22","author":"Zhou","year":"2021","journal-title":"BMC Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btac483\/45026016\/btac483.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/38\/17\/4185\/49889693\/btac483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/38\/17\/4185\/49889693\/btac483.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T04:56:08Z","timestamp":1700801768000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/38\/17\/4185\/6633309"}},"subtitle":[],"editor":[{"given":"Peter","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":62,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btac483","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.17.492306","asserted-by":"object"}]},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,7,7]]}}}