{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:14:31Z","timestamp":1776352471239,"version":"3.51.2"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070247"],"award-info":[{"award-number":["32070247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M661344"],"award-info":[{"award-number":["2019M661344"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Biodiversity Science and Ecological Engineering in Fudan University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Whole-genome duplication events have long been discovered throughout the evolution of eukaryotes, contributing to genome complexity and biodiversity and leaving traces in the descending organisms. Therefore, an accurate and rapid phylogenomic method is needed to identify the retained duplicated genes on various lineages across the target taxonomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here, we present Tree2GD, an integrated method to identify large-scale gene duplication events by automatically perform multiple procedures, including sequence alignment, recognition of homolog, gene tree\/species tree reconciliation, Ks distribution of gene duplicates and synteny analyses. Application of Tree2GD on 2 datasets, 12 metazoan genomes and 68 angiosperms, successfully identifies all reported whole-genome duplication events exhibited by these species, showing effectiveness and efficiency of Tree2GD on phylogenomic analyses of large-scale gene duplications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Tree2GD is written in Python and C++ and is available at https:\/\/github.com\/Dee-chen\/Tree2gd<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac669","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T13:51:03Z","timestamp":1665496263000},"page":"5317-5321","source":"Crossref","is-referenced-by-count":27,"title":["Tree2GD: a phylogenomic method to detect large-scale gene duplication events"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-340X","authenticated-orcid":false,"given":"Duoyuan","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University , Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-161X","authenticated-orcid":false,"given":"Taikui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University , Shanghai 200433, China"},{"name":"Department of Biology, The Eberly College of Science, and The Huck Institutes of the Life Sciences, The Pennsylvania State University , University Park, PA 16802, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University , Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-4422","authenticated-orcid":false,"given":"Hong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biology, The Eberly College of Science, and The Huck Institutes of the Life Sciences, The Pennsylvania State University , University Park, PA 16802, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-0524","authenticated-orcid":false,"given":"Ji","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University , Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"2022113016212016500_btac669-B1","doi-asserted-by":"crossref","first-page":"1241089","DOI":"10.1126\/science.1241089","article-title":"The Amborella genome and the evolution of flowering plants","volume":"342","author":"Albert","year":"2013","journal-title":"Science"},{"key":"2022113016212016500_btac669-B2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nature22380","article-title":"The sunflower genome provides insights into oil metabolism, flowering and asterid evolution","volume":"546","author":"Badouin","year":"2017","journal-title":"Nature"},{"key":"2022113016212016500_btac669-B3","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3732\/ajb.1600113","article-title":"Most compositae (Asteraceae) are descendants of a paleohexaploid and all share a paleotetraploid ancestor with the Calyceraceae","volume":"103","author":"Barker","year":"2016","journal-title":"Am. 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