{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T02:07:18Z","timestamp":1768097238893,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003447","name":"State Scholarships Foundation","doi-asserted-by":"publisher","award":["MIS-5000432"],"award-info":[{"award-number":["MIS-5000432"]}],"id":[{"id":"10.13039\/501100003447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["1780"],"award-info":[{"award-number":["1780"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Europe \u2013 NI4OS Europe\u201d","award":["857645"],"award-info":[{"award-number":["857645"]}]},{"name":"Greek Research & Technology Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The allosteric modulation of peripheral membrane proteins (PMPs) by targeting protein-membrane interactions with drug-like molecules represents a new promising therapeutic strategy for proteins currently considered undruggable. However, the accessibility of protein-membrane interfaces by small molecules has been so far unexplored, possibly due to the complexity of the interface, the limited protein-membrane structural information and the lack of computational workflows to study it. Herein, we present a pipeline for drugging protein-membrane interfaces using the DREAMM (Drugging pRotein mEmbrAne Machine learning Method) web server. DREAMM works in the back end with a fast and robust ensemble machine learning algorithm for identifying protein-membrane interfaces of PMPs. Additionally, DREAMM also identifies binding pockets in the vicinity of the predicted membrane-penetrating amino acids in protein conformational ensembles provided by the user or generated within DREAMM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>DREAMM web server is accessible via https:\/\/dreamm.ni4os.eu.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac680","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T17:15:09Z","timestamp":1668100509000},"page":"5449-5451","source":"Crossref","is-referenced-by-count":17,"title":["DREAMM: a web-based server for drugging protein-membrane interfaces as a novel workflow for targeted drug design"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-8154","authenticated-orcid":false,"given":"Alexios","family":"Chatzigoulas","sequence":"first","affiliation":[{"name":"Biomedical Research Foundation, Academy of Athens , Athens 11527, Greece"},{"name":"Department of Informatics and Telecommunications, National and Kapodistrian University of Athens , Athens 15784, Greece"}]},{"given":"Zoe","family":"Cournia","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation, Academy of Athens , Athens 11527, Greece"},{"name":"Department of Informatics and Telecommunications, National and Kapodistrian University of Athens , Athens 15784, Greece"}]}],"member":"286","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"2022121418374888000_btac680-B1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/wcms.31","article-title":"Metadynamics","volume":"1","author":"Barducci","year":"2011","journal-title":"WIREs Comput. 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