{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:36:21Z","timestamp":1774312581238,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IPL Inria Neuromarkers","award":["ANR-16-CONV-0005"],"award-info":[{"award-number":["ANR-16-CONV-0005"]}]},{"name":"ANR Prairie","award":["ANR-19-P3IA-0001"],"award-info":[{"award-number":["ANR-19-P3IA-0001"]}]},{"name":"ANR SeqDigger","award":["ANR-19-CE45-0008"],"award-info":[{"award-number":["ANR-19-CE45-0008"]}]},{"name":"H2020 ITN ALPACA","award":["956229"],"award-info":[{"award-number":["956229"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Genome wide association studies elucidate links between genotypes and phenotypes. Recent studies point out the interest of conducting such experiments using k-mers as the base signal instead of single-nucleotide polymorphisms. We propose a tool, kmdiff, that performs differential k-mer analyses on large sequencing cohorts in an order of magnitude less time and memory than previously possible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availabilityand implementation<\/jats:title>\n                  <jats:p>https:\/\/github.com\/tlemane\/kmdiff<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac689","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T15:48:36Z","timestamp":1667231316000},"page":"5443-5445","source":"Crossref","is-referenced-by-count":15,"title":["<tt>k<\/tt>\n                  <tt>mdiff<\/tt>, large-scale and user-friendly differential <i>k<\/i>-mer analyses"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-3178","authenticated-orcid":false,"given":"T\u00e9o","family":"Lemane","sequence":"first","affiliation":[{"name":"Univ. Rennes, Inria, CNRS, IRISA - UMR 6074 , Rennes, F-35000 France"}]},{"given":"Rayan","family":"Chikhi","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Sequence Bioinformatics , Paris, F-75015, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-6407","authenticated-orcid":false,"given":"Pierre","family":"Peterlongo","sequence":"additional","affiliation":[{"name":"Univ. Rennes, Inria, CNRS, IRISA - UMR 6074 , Rennes, F-35000 France"}]}],"member":"286","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"2022121418413505900_btac689-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2016.41","article-title":"Identifying lineage effects when controlling for population structure improves power in bacterial association studies","volume":"1","author":"Earle","year":"2016","journal-title":"Nat. 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