{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:25:26Z","timestamp":1773037526017,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DO1257\/4-1"],"award-info":[{"award-number":["DO1257\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SA829\/19-1"],"award-info":[{"award-number":["SA829\/19-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020","award":["835102"],"award-info":[{"award-number":["835102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Single-molecule localization microscopy resolves individual fluorophores or fluorescence-labeled biomolecules. Data are provided as a set of localizations that distribute normally around the true fluorophore position with a variance determined by the localization precision. Characterizing the spatial fluorophore distribution to differentiate between resolution-limited localization clusters, which resemble individual biomolecules, and extended structures, which represent aggregated molecular complexes, is a common challenge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We demonstrate the use of the convex hull and related hull properties of localization clusters for diagnostic purposes, as a parameter for cluster selection or as a tool to determine localization precision.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>https:\/\/github.com\/super-resolution\/Ebert-et-al-2022-supplement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac700","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T15:48:38Z","timestamp":1667231318000},"page":"5421-5429","source":"Crossref","is-referenced-by-count":10,"title":["Convex hull as diagnostic tool in single-molecule localization microscopy"],"prefix":"10.1093","volume":"38","author":[{"given":"Vincent","family":"Ebert","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Biophysics, Julius-Maximilians University , 97074 W\u00fcrzburg, Germany"}]},{"given":"Patrick","family":"Eiring","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biophysics, Julius-Maximilians University , 97074 W\u00fcrzburg, Germany"}]},{"given":"Dominic A","family":"Helmerich","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biophysics, Julius-Maximilians University , 97074 W\u00fcrzburg, Germany"}]},{"given":"Rick","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biophysics, Julius-Maximilians University , 97074 W\u00fcrzburg, Germany"}]},{"given":"Markus","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biophysics, Julius-Maximilians University , 97074 W\u00fcrzburg, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-1182","authenticated-orcid":false,"given":"S\u00f6ren","family":"Doose","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biophysics, Julius-Maximilians University , 97074 W\u00fcrzburg, Germany"}]}],"member":"286","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"2022121418362832500_btac700-B1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nmeth.1627","article-title":"Identification of clustering artifacts in photoactivated localization microscopy","volume":"8","author":"Annibale","year":"2011","journal-title":"Nat. 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