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Researchers have developed several computational methods to predict the potential AMPs from many candidate peptides. With the development of artificial intelligent techniques, the protein structures can be accurately predicted, which are useful for protein sequence and function analysis. Unfortunately, the predicted peptide structure information has not been applied to the field of AMP prediction so as to improve the predictive performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we proposed a computational predictor called sAMPpred-GAT for AMP identification. To the best of our knowledge, sAMPpred-GAT is the first approach based on the predicted peptide structures for AMP prediction. The sAMPpred-GAT predictor constructs the graphs based on the predicted peptide structures, sequence information and evolutionary information. The Graph Attention Network (GAT) is then performed on the graphs to learn the discriminative features. Finally, the full connection networks are utilized as the output module to predict whether the peptides are AMP or not. Experimental results show that sAMPpred-GAT outperforms the other state-of-the-art methods in terms of AUC, and achieves better or highly comparable performance in terms of the other metrics on the eight independent test datasets, demonstrating that the predicted peptide structure information is important for AMP prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>A user-friendly webserver of sAMPpred-GAT can be accessed at http:\/\/bliulab.net\/sAMPpred-GAT and the source code is available at https:\/\/github.com\/HongWuL\/sAMPpred-GAT\/.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac715","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T13:13:07Z","timestamp":1667826787000},"source":"Crossref","is-referenced-by-count":205,"title":["sAMPpred-GAT: prediction of antimicrobial peptide by graph attention network and predicted peptide structure"],"prefix":"10.1093","volume":"39","author":[{"given":"Ke","family":"Yan","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-9469","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081, China"},{"name":"Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology , Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"2023010107525856900_btac715-B1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"2023010107525856900_btac715-B2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/ph6121543","article-title":"Antimicrobial peptides","volume":"6","author":"Bahar","year":"2013","journal-title":"Pharmaceuticals (Basel)"},{"key":"2023010107525856900_btac715-B3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/10408363.2019.1631249","article-title":"Designing and optimizing new antimicrobial peptides: all targets are not the same","volume":"56","author":"Barreto-Santamaria","year":"2019","journal-title":"Crit. 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