{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:14:51Z","timestamp":1775031291163,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cancer Center Support","award":["P30CA118100"],"award-info":[{"award-number":["P30CA118100"]}]},{"name":"Cancer Center Support","award":["R01ES030993-01A1"],"award-info":[{"award-number":["R01ES030993-01A1"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Somatic mutation co-occurrence has been proven to have a profound effect on tumorigenesis. While some studies have been conducted on co-mutations, a centralized resource dedicated to co-mutations in cancer is still lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Using multi-omics data from over 30\u200a000 subjects and 1747 cancer cell lines, we present the Cancer co-mutation database (CoMutDB), the most comprehensive resource devoted to describing cancer co-mutations and their characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The data underlying this article are available in the online database CoMutDB: http:\/\/www.innovebioinfo.com\/Database\/CoMutDB\/Home.php.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac725","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T22:20:47Z","timestamp":1667946047000},"source":"Crossref","is-referenced-by-count":5,"title":["CoMutDB: the landscape of somatic mutation co-occurrence in cancers"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-3698","authenticated-orcid":false,"given":"Limin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Comprehensive Cancer Center, University of New Mexico , Albuquerque, NM 87109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Comprehensive Cancer Center, University of New Mexico , Albuquerque, NM 87109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of South Carolina , Columbia, SC, 29201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-3960","authenticated-orcid":false,"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Comprehensive Cancer Center, University of New Mexico , Albuquerque, NM 87109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"2023010107522886100_btac725-B1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1158\/1078-0432.CCR-17-1841","article-title":"Effects of co-occurring genomic alterations on outcomes in patients with KRAS-mutant non-small cell lung cancer","volume":"24","author":"Arbour","year":"2018","journal-title":"Clin. 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