{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:05:59Z","timestamp":1784109959287,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/V509681\/1"],"award-info":[{"award-number":["BB\/V509681\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The development of new vaccines and antibody therapeutics typically takes several years and requires over $1bn in investment. Accurate knowledge of the paratope (antibody binding site) can speed up and reduce the cost of this process by improving our understanding of antibody\u2013antigen binding. We present Paragraph, a structure-based paratope prediction tool that outperforms current state-of-the-art tools using simpler feature vectors and no antigen information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Source code is freely available at www.github.com\/oxpig\/Paragraph.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac732","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T08:17:00Z","timestamp":1668241020000},"source":"Crossref","is-referenced-by-count":50,"title":["Paragraph\u2014antibody paratope prediction using graph neural networks with minimal feature vectors"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-185X","authenticated-orcid":false,"given":"Lewis","family":"Chinery","sequence":"first","affiliation":[{"name":"Department of Statistics, University of Oxford , Oxford OX1 3LB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newton","family":"Wahome","sequence":"additional","affiliation":[{"name":"GSK Vaccines , Rockville, MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Moal","sequence":"additional","affiliation":[{"name":"GSK R&D , Stevenage SG1 2NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-2252","authenticated-orcid":false,"given":"Charlotte M","family":"Deane","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Oxford , Oxford OX1 3LB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"2023010107525678000_btac732-B1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/bioinformatics\/btac016","article-title":"ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation","volume":"38","author":"Abanades","year":"2022","journal-title":"Bioinformatics"},{"key":"2023010107525678000_btac732-B2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.str.2019.10.011","article-title":"Modeling antibody-antigen complexes by information-driven docking","volume":"28","author":"Ambrosetti","year":"2020","journal-title":"Structure"},{"key":"2023010107525678000_btac732-B3","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1093\/bioinformatics\/btaa644","article-title":"proABC-2: PRediction of AntiBody contacts v2 and its application to information-driven docking","volume":"36","author":"Ambrosetti","year":"2020","journal-title":"Bioinformatics"},{"key":"2023010107525678000_btac732-B4","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1038\/s41596-021-00597-z","article-title":"A practical guide to large-scale docking","volume":"16","author":"Bender","year":"2021","journal-title":"Nat. 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