{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:51:40Z","timestamp":1786683100982,"version":"3.56.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PREDYCTBIO","award":["RYC-2019-027537-I"],"award-info":[{"award-number":["RYC-2019-027537-I"]}]},{"name":"PREDYCTBIO","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"PREDYCTBIO","award":["ED431F 2021\/003"],"award-info":[{"award-number":["ED431F 2021\/003"]}]},{"name":"PREDYCTBIO","award":["PID2020-113992RA-I00"],"award-info":[{"award-number":["PID2020-113992RA-I00"]}]},{"name":"PREDYCTBIO","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria"},{"name":"Universidade de Vigo\/CISUG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>STRIKE-GOLDD is a toolbox that analyses the structural identifiability and observability of possibly non-linear, non-rational ODE models that may have known and unknown inputs. Its broad applicability comes at the expense of a lower computational efficiency than other tools.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>STRIKE-GOLDD 4.0 includes a new algorithm, ProbObsTest, specifically designed for the analysis of rational models. ProbObsTest is significantly faster than the previously available FISPO algorithm when applied to computationally expensive models. Providing both algorithms in the same toolbox allows combining generality and computational efficiency. STRIKE-GOLDD 4.0 is implemented as a Matlab toolbox with a user-friendly graphical interface.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>STRIKE-GOLDD 4.0 is a free and open-source tool available under a GPLv3 license. It can be downloaded from GitHub at https:\/\/github.com\/afvillaverde\/strike-goldd.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac748","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T12:58:50Z","timestamp":1668776330000},"source":"Crossref","is-referenced-by-count":42,"title":["STRIKE-GOLDD 4.0: user-friendly, efficient analysis of structural identifiability and observability"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-1639","authenticated-orcid":false,"given":"Sandra","family":"D\u00edaz-Seoane","sequence":"first","affiliation":[{"name":"Department of Systems and Control Engineering, Universidade de Vigo , Galicia, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-4462","authenticated-orcid":false,"given":"Xabier","family":"Rey Barreiro","sequence":"additional","affiliation":[{"name":"Department of Systems and Control Engineering, Universidade de Vigo , Galicia, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7401-7380","authenticated-orcid":false,"given":"Alejandro F","family":"Villaverde","sequence":"additional","affiliation":[{"name":"Department of Systems and Control Engineering, Universidade de Vigo , Galicia, 36310 Vigo, Spain"},{"name":"CITMAga , Galicia, 15782 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"2023010107514000800_btac748-B1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cmpb.2007.07.002","article-title":"DAISY: a new software tool to test global identifiability of biological and physiological systems","volume":"88","author":"Bellu","year":"2007","journal-title":"Comput. 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