{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:32:51Z","timestamp":1776987171766,"version":"3.51.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Protection Research Unit in Genomics and Enabling Data"},{"DOI":"10.13039\/501100000266","name":"UK Engineering and Physical Sciences Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["EP\/S022244\/1"],"award-info":[{"award-number":["EP\/S022244\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EPSRC Centre for Doctoral Training in Mathematics for Real-World Systems II"},{"name":"UK\u2019s Crop Diversity Bioinformatics HPC"},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/S019669\/1"],"award-info":[{"award-number":["BB\/S019669\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>The ability to distinguish imported cases from locally acquired cases has important consequences for the selection of public health control strategies. Genomic data can be useful for this, for example, using a phylogeographic analysis in which genomic data from multiple locations are compared to determine likely migration events between locations. However, these methods typically require good samples of genomes from all locations, which is rarely available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we propose an alternative approach that only uses genomic data from a location of interest. By comparing each new case with previous cases from the same location, we are able to detect imported cases, as they have a different genealogical distribution than that of locally acquired cases. We show that, when variations in the size of the local population are accounted for, our method has good sensitivity and excellent specificity for the detection of imports. We applied our method to data simulated under the structured coalescent model and demonstrate relatively good performance even when the local population has the same size as the external population. Finally, we applied our method to several recent genomic datasets from both bacterial and viral pathogens, and show that it can, in a matter of seconds or minutes, deliver important insights on the number of imports to a geographically limited sample of a pathogen population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The R package DetectImports is freely available from https:\/\/github.com\/xavierdidelot\/DetectImports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac761","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T16:59:07Z","timestamp":1669309147000},"source":"Crossref","is-referenced-by-count":5,"title":["Distinguishing imported cases from locally acquired cases within a geographically limited genomic sample of an infectious disease"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-500X","authenticated-orcid":false,"given":"Xavier","family":"Didelot","sequence":"first","affiliation":[{"name":"School of Life Sciences and Department of Statistics, University of Warwick , Coventry CV4 7AL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Helekal","sequence":"additional","affiliation":[{"name":"Centre for Doctoral Training in Mathematics for Real-World Systems, University of Warwick , Coventry CV4 7AL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kendall","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Department of Statistics, University of Warwick , Coventry CV4 7AL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Ribeca","sequence":"additional","affiliation":[{"name":"Gastrointestinal Bacteria Reference Unit, UK Health Security Agency , London NW9 5EQ, UK"},{"name":"Biomathematics and Statistics Scotland, The James Hutton Institute , Edinburgh EH9 3FD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"2023010107515288600_btac761-B1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syw054","article-title":"Emerging concepts of data integration in pathogen phylodynamics","author":"Baele","year":"2016","journal-title":"Syst. Biol"},{"key":"2023010107515288600_btac761-B2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Statisitical Soc. Ser. B"},{"key":"2023010107515288600_btac761-B3","author":"Betancourt","year":"2018"},{"key":"2023010107515288600_btac761-B4","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1128\/JCM.01453-07","article-title":"Concordance between Neisseria gonorrhoeae genotypes recovered from known sexual contacts","volume":"45","author":"Bilek","year":"2007","journal-title":"J. Clin. Microbiol"},{"key":"2023010107515288600_btac761-B5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tree.2010.08.010","article-title":"Three roads diverged? Routes to phylogeographic inference","volume":"25","author":"Bloomquist","year":"2010","journal-title":"Trends Ecol. Evol"},{"key":"2023010107515288600_btac761-B6","doi-asserted-by":"crossref","first-page":"e1006650","DOI":"10.1371\/journal.pcbi.1006650","article-title":"BEAST 2.5: an advanced software platform for Bayesian evolutionary analysis","volume":"15","author":"Bouckaert","year":"2019","journal-title":"PLoS Comput. Biol"},{"key":"2023010107515288600_btac761-B7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41586-021-04385-3","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","volume":"602","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"2023010107515288600_btac761-B8","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v076.i01","article-title":"Stan: a probabilistic programming language","volume":"76","author":"Carpenter","year":"2017","journal-title":"J. Stat. Softw"},{"key":"2023010107515288600_btac761-B9","doi-asserted-by":"crossref","first-page":"111186","DOI":"10.1016\/j.jtbi.2022.111186","article-title":"The bounded coalescent model: conditioning a genealogy on a minimum root date","volume":"548","author":"Carson","year":"2022","journal-title":"J. Theor. Biol"},{"key":"2023010107515288600_btac761-B10","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg3055","article-title":"Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England","volume":"372","author":"Davies","year":"2021","journal-title":"Science"},{"key":"2023010107515288600_btac761-B11","doi-asserted-by":"crossref","first-page":"e1005421","DOI":"10.1371\/journal.pgen.1005421","article-title":"New routes to phylogeography: a Bayesian structured coalescent approximation","volume":"11","author":"De Maio","year":"2015","journal-title":"PLoS Genet"},{"key":"2023010107515288600_btac761-B12","doi-asserted-by":"crossref","first-page":"e1005130","DOI":"10.1371\/journal.pcbi.1005130","article-title":"SCOTTI: efficient reconstruction of transmission within outbreaks with the structured coalescent","volume":"12","author":"De Maio","year":"2016","journal-title":"PLoS Comput. Biol"},{"key":"2023010107515288600_btac761-B13","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1534\/genetics.106.063305","article-title":"Inference of bacterial microevolution using multilocus sequence data","volume":"175","author":"Didelot","year":"2007","journal-title":"Genetics"},{"key":"2023010107515288600_btac761-B14","doi-asserted-by":"crossref","first-page":"20210246","DOI":"10.1098\/rstb.2021.0246","article-title":"A scalable analytical approach from bacterial genomes to epidemiology","volume":"377","author":"Didelot","year":"2022","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci"},{"key":"2023010107515288600_btac761-B15","doi-asserted-by":"crossref","first-page":"e1004041","DOI":"10.1371\/journal.pcbi.1004041","article-title":"ClonalFrameML: efficient inference of recombination in whole bacterial genomes","volume":"11","author":"Didelot","year":"2015","journal-title":"PLoS Comput. Biol"},{"key":"2023010107515288600_btac761-B16","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1534\/genetics.110.120121","article-title":"Inference of homologous recombination in bacteria using whole-genome sequences","volume":"186","author":"Didelot","year":"2010","journal-title":"Genetics"},{"key":"2023010107515288600_btac761-B17","doi-asserted-by":"crossref","first-page":"e1002191","DOI":"10.1371\/journal.pgen.1002191","article-title":"Recombination and population structure in Salmonella enterica","volume":"7","author":"Didelot","year":"2011","journal-title":"PLoS Genet"},{"key":"2023010107515288600_btac761-B18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1471-2164-13-256","article-title":"Impact of homologous and non-homologous recombination in the genomic evolution of Escherichia coli","volume":"13","author":"Didelot","year":"2012","journal-title":"BMC Genomics"},{"key":"2023010107515288600_btac761-B19","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/molbev\/msu121","article-title":"Bayesian inference of infectious disease transmission from whole genome sequence data","volume":"31","author":"Didelot","year":"2014","journal-title":"Mol. Biol. Evol"},{"key":"2023010107515288600_btac761-B20","doi-asserted-by":"crossref","first-page":"e00525\u201316","DOI":"10.1128\/mBio.00525-16","article-title":"Genomic analysis and comparison of two gonorrhea outbreaks","volume":"7","author":"Didelot","year":"2016","journal-title":"MBio"},{"key":"2023010107515288600_btac761-B21","first-page":"997","article-title":"Genomic infectious disease epidemiology in partially sampled and ongoing outbreaks","volume":"34","author":"Didelot","year":"2017","journal-title":"Mol. Biol. Evol"},{"key":"2023010107515288600_btac761-B22","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1093\/nar\/gky783","article-title":"Bayesian inference of ancestral dates on bacterial phylogenetic trees","volume":"46","author":"Didelot","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023010107515288600_btac761-B23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/molbev\/msaa193","article-title":"Additive uncorrelated relaxed clock models for the dating of genomic epidemiology phylogenies","volume":"38","author":"Didelot","year":"2021","journal-title":"Mol. Biol. Evol"},{"key":"2023010107515288600_btac761-B24","author":"Didelot","year":"2021"},{"key":"2023010107515288600_btac761-B25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.ge.29.120195.002153","article-title":"Coalescents and genealogical structure under neutrality","volume":"29","author":"Donnelly","year":"1995","journal-title":"Annu. Rev. Genet"},{"key":"2023010107515288600_btac761-B26","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/genetics\/161.3.1307","article-title":"Estimating mutation parameters, population history and genealogy simultaneously from temporally spaced sequence data","volume":"161","author":"Drummond","year":"2002","journal-title":"Genetics"},{"key":"2023010107515288600_btac761-B27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0169-5347(03)00216-7","article-title":"Measurably evolving populations","volume":"18","author":"Drummond","year":"2003","journal-title":"Trends Ecol. Evol"},{"key":"2023010107515288600_btac761-B28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature22040","article-title":"Virus genomes reveal factors that spread and sustained the ebola epidemic","volume":"544","author":"Dudas","year":"2017","journal-title":"Nature"},{"key":"2023010107515288600_btac761-B29","doi-asserted-by":"crossref","DOI":"10.1126\/science.abl9551","article-title":"Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant","volume":"374","author":"Elliott","year":"2021","journal-title":"Science"},{"key":"2023010107515288600_btac761-B30","first-page":"733","article-title":"Posterior predictive assessment of model fitness via realized discrepancies","volume":"6","author":"Gelman","year":"1996","journal-title":"Stat. Sin"},{"key":"2023010107515288600_btac761-B31","first-page":"189","article-title":"Why we (usually) don\u2019t have to worry about multiple comparisons","volume":"5","author":"Gelman","year":"2012","journal-title":"J. Res. Educ. Effect"},{"key":"2023010107515288600_btac761-B32","first-page":"299","article-title":"Classes of kernels for machine learning: a statistics perspective","volume":"2","author":"Genton","year":"2002","journal-title":"J. Mach. Learn. Res"},{"key":"2023010107515288600_btac761-B33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1098\/rstb.1994.0079","article-title":"Sampling theory for neutral alleles in a varying environment","volume":"344","author":"Griffiths","year":"1994","journal-title":"Philos. Trans. R. Soc. B"},{"key":"2023010107515288600_btac761-B34","first-page":"syab095","article-title":"Bayesian inference of clonal expansions in a dated phylogeny","author":"Helekal","year":"2021","journal-title":"Syst. Biol."},{"key":"2023010107515288600_btac761-B35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1755-0998.2011.02988.x","article-title":"Skyline-plot methods for estimating demographic history from nucleotide sequences","volume":"11","author":"Ho","year":"2011","journal-title":"Mol. Ecol. Resour"},{"key":"2023010107515288600_btac761-B36","doi-asserted-by":"crossref","first-page":"17522","DOI":"10.1073\/pnas.1308632110","article-title":"Tracking the establishment of local endemic populations of an emergent enteric pathogen","volume":"110","author":"Holt","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023010107515288600_btac761-B37","first-page":"1","article-title":"Gene genealogies and the coalescent process","volume":"7","author":"Hudson","year":"1990","journal-title":"Oxford Surv. Evol. Biol"},{"key":"2023010107515288600_btac761-B38","doi-asserted-by":"crossref","first-page":"e1003457","DOI":"10.1371\/journal.pcbi.1003457","article-title":"Bayesian reconstruction of disease outbreaks by combining epidemiologic and genomic data","volume":"10","author":"Jombart","year":"2014","journal-title":"PLoS Comput. Biol"},{"key":"2023010107515288600_btac761-B39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/1755-0998.12630","article-title":"Phylodyn: an R package for phylodynamic simulation and inference","volume":"17","author":"Karcher","year":"2017","journal-title":"Mol. Ecol. Resour"},{"key":"2023010107515288600_btac761-B40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0304-4149(82)90011-4","article-title":"The coalescent","volume":"13","author":"Kingman","year":"1982","journal-title":"Stoch. Process. Appl"},{"key":"2023010107515288600_btac761-B41","doi-asserted-by":"crossref","first-page":"e1005495","DOI":"10.1371\/journal.pcbi.1005495","article-title":"Simultaneous inference of phylogenetic and transmission trees in infectious disease outbreaks","volume":"13","author":"Klinkenberg","year":"2017","journal-title":"PLoS Comput. Biol"},{"key":"2023010107515288600_btac761-B42","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1093\/bioinformatics\/btv378","article-title":"An efficient Bayesian inference framework for coalescent-based nonparametric phylodynamics","volume":"31","author":"Lan","year":"2015","journal-title":"Bioinformatics"},{"key":"2023010107515288600_btac761-B43","doi-asserted-by":"crossref","first-page":"e1000520","DOI":"10.1371\/journal.pcbi.1000520","article-title":"Bayesian phylogeography finds its roots","volume":"5","author":"Lemey","year":"2009","journal-title":"PLoS Comput. Biol"},{"key":"2023010107515288600_btac761-B44","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1093\/molbev\/msx186","article-title":"The structured coalescent and its approximations","volume":"34","author":"Muller","year":"2017","journal-title":"Mol. Biol. Evol"},{"key":"2023010107515288600_btac761-B45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00173909","article-title":"The coalescent and the genealogical process in geographically structured population","volume":"29","author":"Notohara","year":"1990","journal-title":"J. Math. Biol"},{"key":"2023010107515288600_btac761-B46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/10635150802044003","article-title":"Accounting for phylogenetic uncertainty in biogeography: a bayesian approach to dispersal-vicariance analysis of the thrushes (aves: turdus)","volume":"57","author":"Nylander","year":"2008","journal-title":"Syst. Biol"},{"key":"2023010107515288600_btac761-B47","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/gbe\/evz119","article-title":"The population structure of Pseudomonas aeruginosa is characterized by genetic isolation of exoU+ and exoS+ lineages","volume":"11","author":"Ozer","year":"2019","journal-title":"Genome Biol. Evol"},{"key":"2023010107515288600_btac761-B48","doi-asserted-by":"crossref","first-page":"e9490","DOI":"10.1371\/journal.pone.0009490","article-title":"FastTree 2 \u2013 approximately maximum-likelihood trees for large alignments","volume":"5","author":"Price","year":"2010","journal-title":"PLoS One"},{"key":"2023010107515288600_btac761-B49","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrg2583","article-title":"Evolutionary analysis of the dynamics of viral infectious disease","volume":"10","author":"Pybus","year":"2009","journal-title":"Nat. Rev. Genet"},{"key":"2023010107515288600_btac761-B50","author":"Riutort-Mayol","year":"2020"},{"key":"2023010107515288600_btac761-B51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"key":"2023010107515288600_btac761-B52","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vex042","article-title":"TreeTime: maximum likelihood phylodynamic analysis","volume":"4","author":"Sagulenko","year":"2018","journal-title":"Virus Evol"},{"key":"2023010107515288600_btac761-B53","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/21665044.2016.1228326","article-title":"Distinguishing epidemiological features of the 2013\u20132016 west africa ebola virus disease outbreak","volume":"3","author":"Shultz","year":"2016","journal-title":"Disaster Health"},{"key":"2023010107515288600_btac761-B54","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11222-019-09886-w","article-title":"Hilbert space methods for reduced-rank Gaussian process regression","volume":"30","author":"Solin","year":"2020","journal-title":"Stat. Comput"},{"key":"2023010107515288600_btac761-B55","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/1467-9868.00353","article-title":"Bayesian measures of model complexity and fit","volume":"64","author":"Spiegelhalter","year":"2002","journal-title":"J. R. Stat. Soc. B"},{"key":"2023010107515288600_btac761-B56","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vey016","article-title":"Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10","volume":"4","author":"Suchard","year":"2018","journal-title":"Virus Evol"},{"key":"2023010107515288600_btac761-B57","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/molbev\/mst057","article-title":"A stochastic simulator of birth-death master equations with application to phylodynamics","volume":"30","author":"Vaughan","year":"2013","journal-title":"Mol. Biol. Evol"},{"key":"2023010107515288600_btac761-B58","first-page":"667","article-title":"Rank-normalization, folding, and localization: an improved R hat for assessing convergence of MCMC","volume":"16","author":"Vehtarh","year":"2021","journal-title":"Bayesian Anal"},{"key":"2023010107515288600_btac761-B59","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/sysbio\/syy007","article-title":"Modeling the growth and decline of pathogen effective population size provides insight into epidemic dynamics and drivers of antimicrobial resistance","volume":"67","author":"Volz","year":"2018","journal-title":"Syst. Biol"},{"key":"2023010107515288600_btac761-B60","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vex025","article-title":"Scalable relaxed clock phylogenetic dating","volume":"3","author":"Volz","year":"2017","journal-title":"Virus Evol"},{"key":"2023010107515288600_btac761-B61","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/S0140-6736(00)03234-7","article-title":"A prospective social and molecular investigation of gonococcal transmission","volume":"356","author":"Ward","year":"2000","journal-title":"Lancet"},{"key":"2023010107515288600_btac761-B62","volume-title":"Gaussian Processes for Machine Learning","author":"Williams","year":"2006"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btac761\/47774039\/btac761.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/39\/1\/btac761\/48448702\/btac761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/39\/1\/btac761\/48448702\/btac761.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T10:21:49Z","timestamp":1728469309000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/doi\/10.1093\/bioinformatics\/btac761\/6849542"}},"subtitle":[],"editor":[{"given":"Russell","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,11,28]]},"published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btac761","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.15.500228","asserted-by":"object"}]},"ISSN":["1367-4811"],"issn-type":[{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,28]]},"article-number":"btac761"}}