{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:17Z","timestamp":1772138057312,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vanderbilt University Department of Biostatistics Development","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Making sense of networked multivariate association patterns is vitally important to many areas of high-dimensional analysis. Unfortunately, as the data-space dimensions grow, the number of association pairs increases in O(n2); this means that traditional visualizations such as heatmaps quickly become too complicated to parse effectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we present associationSubgraphs: a new interactive visualization method to quickly and intuitively explore high-dimensional association datasets using network percolation and clustering. The goal is to provide an efficient investigation of association subgraphs, each containing a subset of variables with stronger and more frequent associations among themselves than the remaining variables outside the subset, by showing the entire clustering dynamics and providing subgraphs under all possible cutoff values at once. Particularly, we apply associationSubgraphs to a phenome-wide multimorbidity association matrix generated from an electronic health record and provide an online, interactive demonstration for exploring multimorbidity subgraphs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>An R package implementing both the algorithm and visualization components of associationSubgraphs is available at https:\/\/github.com\/tbilab\/associationsubgraphs. Online documentation is available at https:\/\/prod.tbilab.org\/associationsubgraphs_info\/. A demo using a multimorbidity association matrix is available at https:\/\/prod.tbilab.org\/associationsubgraphs-example\/.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac780","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T19:01:55Z","timestamp":1670353315000},"source":"Crossref","is-referenced-by-count":5,"title":["Interactive network-based clustering and investigation of multimorbidity association matrices with associationSubgraphs"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4704-7124","authenticated-orcid":false,"given":"Nick","family":"Strayer","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University , Nashville, TN 37232, 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University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana K","family":"Shirey-Rice","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin M","family":"Balko","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-773X","authenticated-orcid":false,"given":"Douglas B","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Drug Safety and Immunology, Vanderbilt University Medical Center , Nashville, TN 37232, USA"},{"name":"Institute for Immunology and Infectious Diseases, Murdoch University , Murdoch, WA 6150, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Bick","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd L","family":"Edwards","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Digna R","family":"Velez Edwards","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill M","family":"Pulley","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, TN 37232, USA"},{"name":"Department of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quinn S","family":"Wells","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN 37232, USA"},{"name":"Department of Cardiovascular Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R","family":"Savona","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy J","family":"Cox","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN 37232, USA"},{"name":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University Medical Center , Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas M","family":"Ruderfer","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN 37232, 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