{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:56:21Z","timestamp":1780102581764,"version":"3.54.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","award":["IASIS_727658"],"award-info":[{"award-number":["IASIS_727658"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","award":["INFORE_825080"],"award-info":[{"award-number":["INFORE_825080"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Biological condensates are membraneless organelles with different material properties. Proteins and RNAs are the main components, but most of their interactions are still unknown. Here, we introduce PRALINE, a database for the interrogation of proteins and RNAs contained in stress granules, processing bodies and other assemblies including droplets and amyloids. PRALINE provides information about the predicted and experimentally validated protein\u2013protein, protein\u2013RNA and RNA\u2013RNA interactions. For proteins, it reports the liquid\u2013liquid phase separation and liquid\u2013solid phase separation propensities. For RNAs, it provides information on predicted secondary structure content. PRALINE shows detailed information on human single-nucleotide variants, their clinical significance and presence in protein and RNA binding sites, and how they can affect condensates\u2019 physical properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>PRALINE is freely accessible on the web at http:\/\/praline.tartaglialab.com.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac847","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T17:44:15Z","timestamp":1672422255000},"source":"Crossref","is-referenced-by-count":8,"title":["The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates"],"prefix":"10.1093","volume":"39","author":[{"given":"Andrea","family":"Vandelli","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona , Barcelona 08193, Spain"},{"name":"Universitat Pompeu Fabra (UPF) , Barcelona 08003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Arnal Segura","sequence":"additional","affiliation":[{"name":"Center for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT) , Genova 16152, Italy"},{"name":"Department of Biology and Biotechnologies, University Sapienza Rome , Roma 00185, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Monti","sequence":"additional","affiliation":[{"name":"Center for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT) , Genova 16152, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-3210","authenticated-orcid":false,"given":"Jonathan","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Center for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT) , Genova 16152, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Broglia","sequence":"additional","affiliation":[{"name":"Center for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT) , Genova 16152, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Colantoni","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnologies, University Sapienza Rome , Roma 00185, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sanchez de Groot","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona , Barcelona 08193, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Torrent Burgas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de 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