{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:01:35Z","timestamp":1778000495509,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220530152409020"],"award-info":[{"award-number":["JCYJ20220530152409020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Many studies have shown that IDH mutation and 1p\/19q co-deletion can serve as prognostic signatures of glioma. Although these genetic variations affect the expression of one or more genes, the prognostic value of gene expression related to IDH and 1p\/19q status is still unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We constructed an ensemble gene pair signature for the risk evaluation and survival prediction of glioma based on the prior knowledge of the IDH and 1p\/19q status. First, we separately built two gene pair signatures IDH-GPS and 1p\/19q-GPS and elucidated that they were useful transcriptome markers projecting from corresponding genome variations. Then, the gene pairs in these two models were assembled to develop an integrated model named Glioma Prognostic Gene Pair Signature (GPGPS), which demonstrated high area under the curves (AUCs) to predict 1-, 3- and 5-year overall survival (0.92, 0.88 and 0.80) of glioma. GPGPS was superior to the single GPSs and other existing prognostic signatures (avg AUC\u2009=\u20090.70, concordance index\u2009=\u20090.74). In conclusion, the ensemble prognostic signature with 10 gene pairs could serve as an independent predictor for risk stratification and survival prediction in glioma. This study shed light on transferring knowledge from genetic alterations to expression changes to facilitate prognostic studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Codes are available at https:\/\/github.com\/Kimxbzheng\/GPGPS.git<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btac850","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T01:26:53Z","timestamp":1673659613000},"source":"Crossref","is-referenced-by-count":19,"title":["GPGPS: a robust prognostic gene pair signature of glioma ensembling <i>IDH<\/i> mutation and 1p\/19q co-deletion"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-383X","authenticated-orcid":false,"given":"Lixin","family":"Cheng","sequence":"first","affiliation":[{"name":"Shenzhen People\u2019s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medicine College of Jinan University , Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haonan","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medicine College of Jinan University , Shenzhen 518020, China"},{"name":"Department of Geriatrics, Shenzhen Clinical Research Center for Aging , Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xubin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medicine College of Jinan University , Shenzhen 518020, China"},{"name":"Department of Computer Science and Engineering, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College , Shantou 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medicine College of Jinan University , Shenzhen 518020, China"},{"name":"Department of Geriatrics, Shenzhen Clinical Research Center for Aging , Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medicine College of Jinan University , Shenzhen 518020, China"},{"name":"Department of Computer Science and Engineering, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Hong Kong Genome Institute, Shatin, New Territories , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"International Digital Economy Academy , Shenzhen 518020, 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