{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:11:21Z","timestamp":1773695481853,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EPSRC and the Alan Turing Institute","award":["EP\/R044732\/1"],"award-info":[{"award-number":["EP\/R044732\/1"]}]},{"name":"EPSRC and the Alan Turing Institute","award":["EP\/V049208\/1"],"award-info":[{"award-number":["EP\/V049208\/1"]}]},{"name":"EPSRC and the Alan Turing Institute","award":["EP\/N510129\/1"],"award-info":[{"award-number":["EP\/N510129\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The Wright\u2013Fisher diffusion is important in population genetics in modelling the evolution of allele frequencies over time subject to the influence of biological phenomena such as selection, mutation and genetic drift. Simulating the paths of the process is challenging due to the form of the transition density. We present EWF, a robust and efficient sampler which returns exact draws for the diffusion and diffusion bridge processes, accounting for general models of selection including those with frequency dependence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Given a configuration of selection, mutation and endpoints, EWF returns draws at the requested sampling times from the law of the corresponding Wright\u2013Fisher process. Output was validated by comparison to approximations of the transition density via the Kolmogorov\u2013Smirnov test and QQ plots.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>All softwares are available at https:\/\/github.com\/JaroSant\/EWF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad017","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T17:40:21Z","timestamp":1673458821000},"source":"Crossref","is-referenced-by-count":8,"title":["EWF: simulating exact paths of the Wright\u2013Fisher diffusion"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-7240","authenticated-orcid":false,"given":"Jaromir","family":"Sant","sequence":"first","affiliation":[{"name":"Department of Statistics, University of Warwick , Coventry CV4 7AL, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-4205","authenticated-orcid":false,"given":"Paul A","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Warwick , Coventry CV4 7AL, UK"},{"name":"Department of Computer Science, University of Warwick , Coventry CV4 7AL, UK"},{"name":"The Alan Turing Institute, British Library , London NW1 2DB, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-8777","authenticated-orcid":false,"given":"Jere","family":"Koskela","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Warwick , Coventry CV4 7AL, UK"}]},{"given":"Dario","family":"Span\u00f2","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Warwick , Coventry CV4 7AL, UK"}]}],"member":"286","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"2023011809301896600_btad017-B1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1534\/genetics.107.085019","article-title":"Estimation of 2Nes from temporal allele frequency data","volume":"179","author":"Bollback","year":"2008","journal-title":"Genetics"},{"key":"2023011809301896600_btad017-B2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10543-011-0351-3","article-title":"A boundary preserving numerical algorithm for the Wright\u2013Fisher model with mutation","volume":"52","author":"Dangerfield","year":"2012","journal-title":"Bit Numer. 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