{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:42:22Z","timestamp":1753875742020,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Summary<\/jats:title><jats:p>Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https:\/\/github.com\/R-GENLIB\/GENLIB. Examples can be accessed at https:\/\/github.com\/R-GENLIB\/simuhaplo_functions.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad136","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T14:26:19Z","timestamp":1679063179000},"source":"Crossref","is-referenced-by-count":1,"title":["GENLIB: new function to simulate haplotype transmission in large complex genealogies"],"prefix":"10.1093","volume":"39","author":[{"given":"Mohan","family":"Rakesh","sequence":"first","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa , Ottawa, Ontario, Canada"}]},{"given":"H\u00e9l\u00e8ne","family":"V\u00e9zina","sequence":"additional","affiliation":[{"name":"Projet BALSAC, Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi , Chicoutimi, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement des sciences humaines et sociales, Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi , Chicoutimi, Qu\u00e9bec, Canada"},{"name":"Centre intersectoriel en sant\u00e9 durable, Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi , Chicoutimi, Qu\u00e9bec, Canada"}]},{"given":"Catherine","family":"Laprise","sequence":"additional","affiliation":[{"name":"Centre intersectoriel en sant\u00e9 durable, Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi , Chicoutimi, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement des sciences fondamentales, Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi , Chicoutimi, Qu\u00e9bec, Canada"}]},{"given":"Ellen E","family":"Freeman","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa , Ottawa, Ontario, Canada"},{"name":"Centre de Recherche, H\u00f4pital Maisonneuve-Rosemont , Montr\u00e9al, Qu\u00e9bec, Canada"}]},{"given":"Kelly M","family":"Burkett","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, University of Ottawa , Ottawa, Ontario, 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