{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:17Z","timestamp":1772138057605,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871921"],"award-info":[{"award-number":["81871921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>We developed the eccDB database to integrate available resources for extrachromosomal circular DNA (eccDNA) data. eccDB is a comprehensive repository for storing, browsing, searching, and analyzing eccDNAs from multispecies. The database provides regulatory and epigenetic information on eccDNAs, with a focus on analyzing intrachromosomal and interchromosomal interactions to predict their transcriptional regulatory functions. Moreover, eccDB identifies eccDNAs from unknown DNA sequences and analyzes the functional and evolutionary relationships of eccDNAs among different species. Overall, eccDB offers web-based analytical tools and a comprehensive resource for biologists and clinicians to decipher the molecular regulatory mechanisms of eccDNAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>eccDB is freely available at http:\/\/www.xiejjlab.bio\/eccDB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad173","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T13:04:03Z","timestamp":1680699843000},"source":"Crossref","is-referenced-by-count":17,"title":["eccDB: a comprehensive repository for eccDNA-mediated chromatin contacts in multi-species"],"prefix":"10.1093","volume":"39","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University , Dongguan 523808, China"},{"name":"Institute of Biochemistry & Molecular Biology, Guangdong Medical University , Zhanjiang 524023, China"}]},{"given":"Bo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Jiaying University , Meizhou 514031, China"}]},{"given":"Guo-You","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Harbin Medical University, Daqing Campus , Daqing 163319, China"}]},{"given":"Jian-Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University , Jinan 250012, China"}]},{"given":"Hao-Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Harbin Medical University, Daqing Campus , Daqing 163319, China"}]},{"given":"Yu-Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical College of Shantou University , Shantou 515063, China"}]},{"given":"Yan-Shang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical College of Shantou University , Shantou 515063, China"}]},{"given":"Tai-Song","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical College of Shantou University , Shantou 515063, China"}]},{"given":"Jin-Cheng","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China"}]},{"given":"Xue-Cang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Harbin Medical University, Daqing Campus , Daqing 163319, 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