{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:22:45Z","timestamp":1774909365020,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Studying ageing effects on molecules is an important new topic for life science. To perform such studies, the need for data, models, algorithms, and tools arises to elucidate molecular mechanisms. GTEx (standing for Genotype-Tissue Expression) portal is a web-based data source allowing to retrieve patients\u2019 transcriptomics data annotated with tissues, gender, and age information. It represents the more complete data sources for ageing effects studies. Nevertheless, it lacks functionalities to query data at the sex\/age level, as well as tools for protein interaction studies, thereby limiting ageing studies. As a result, users need to download query results to proceed to further analysis, such as retrieving the expression of a given gene on different age (or sex) classes in many tissues.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We present the GTExVisualizer, a platform to query and analyse GTEx data. This tool contains a web interface able to: (i) graphically represent and study query results; (ii) analyse genes using sex\/age expression patterns, also integrated with network-based modules; and (iii) report results as plot-based representation as well as (gene) networks. Finally, it allows the user to obtain basic statistics which evidence differences in gene expression among sex\/age groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The GTExVisualizer novelty consists in providing a tool for studying ageing\/sex-related effects on molecular processes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>GTExVisualizer is available at: http:\/\/gtexvisualizer.herokuapp.com. The source code and data are available at: https:\/\/github.com\/UgoLomoio\/gtex_visualizer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad303","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T13:52:55Z","timestamp":1683553975000},"source":"Crossref","is-referenced-by-count":10,"title":["GTExVisualizer: a web platform for supporting ageing studies"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-2997","authenticated-orcid":false,"given":"Pietro Hiram","family":"Guzzi","sequence":"first","affiliation":[{"name":"Department of Surgical and Medical Sciences, Magna Graecia University of Catanzaro, Viale Europa , Catanzaro 88100, Italy"},{"name":"Data Analytics Research Center, University of Catanzaro , Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugo","family":"Lomoio","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences, Magna Graecia University of Catanzaro, Viale Europa , Catanzaro 88100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-0294","authenticated-orcid":false,"given":"Pierangelo","family":"Veltri","sequence":"additional","affiliation":[{"name":"DIMES, University of Calabria , Via Pietro Bucci , Rende, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"2024022316454908000_btad303-B1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.molcel.2016.05.013","article-title":"The aging epigenome","volume":"62","author":"Booth","year":"2016","journal-title":"Mol Cell"},{"key":"2024022316454908000_btad303-B2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10522-017-9683-y","article-title":"A review of supervised machine learning applied to ageing research","volume":"18","author":"Fabris","year":"2017","journal-title":"Biogerontology"},{"key":"2024022316454908000_btad303-B3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (gtex) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat Genet"},{"key":"2024022316454908000_btad303-B4","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1016\/j.csbj.2021.07.002","article-title":"Exploiting the molecular basis of age and gender differences in outcomes of sars-cov-2 infections","volume":"19","author":"Mercatelli","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"2024022316454908000_btad303-B5","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The string database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btad303\/50244573\/btad303.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/39\/5\/btad303\/56748270\/btad303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/39\/5\/btad303\/56748270\/btad303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T16:46:02Z","timestamp":1708706762000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/doi\/10.1093\/bioinformatics\/btad303\/7156837"}},"subtitle":[],"editor":[{"given":"Can","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,4]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btad303","relation":{},"ISSN":["1367-4811"],"issn-type":[{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,5,1]]},"article-number":"btad303"}}